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EC number: 211-746-3 | CAS number: 693-23-2
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- Appearance / physical state / colour
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- Particle size distribution (Granulometry)
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicological Summary
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Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Influence of sodium salts of saturated medium chain length (C6, C9, C10 and C12) dicarboxylic acids on the uterine horn of rat in vitro
- Author:
- Mingrone G, Mancinelli R and Metro D
- Year:
- 1 988
- Bibliographic source:
- Quart. J. Exp. Physiol. 73, 153-162
Materials and methods
- Principles of method if other than guideline:
- The in vitro action of C6, C9, C10 and C12 dicarboxylic acid sodium salts on the mechanical and extracellular electrical activity on the uterine
horn of rats was studied - Type of method:
- in vitro
Test material
- Reference substance name:
- Dodecanedioic acid
- EC Number:
- 211-746-3
- EC Name:
- Dodecanedioic acid
- Cas Number:
- 693-23-2
- Molecular formula:
- C12H22O4
- IUPAC Name:
- dodecanedioic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 35 female Wistar rats in natural oestrus and weighing 250-300 g
Administration / exposure
- Details on exposure:
- The in vitro action of C6, C9, C10 and C12 dicarboxylic acid sodium salts on the mechanical and extracellular electrical activity on the uterine horn
of rats was studied:
- Rats: 35 female Wistar rats in natural oestrus and weighing 250-300 g were anesthetized. After a mid-line incision, both uterine horns were
quickly removed and placed in a bath of Krebs solution (37 °C, pH 7.4).
- For measuring only mechanical events, a vertical arrangement was used. The ovarian end of a uterine horn was ligated and tied to an isometric
force transducer connected to a chart recorder; the cervical end of the horn was connected to a hook in the bath.
- For measuring mechanical and electrical events, a similar arrangement in horizontal position was used. The extracellular electrical activity was
recorded by means of a glass capillary pressure electrode. Mechanical and electrical activities were simultaneously recorded.
- Concentrations of acetylcholine, oxytocin and prostaglandins evoking maximal isometrical contraction were checked for each uterine horn.
- Dicarboxylic salt effect was measured as the percentage reduction in amplitude and in frequency of the spontaneous activity and as the
percentage reduction for only the amplitude of the evoked contraction.
Results and discussion
Any other information on results incl. tables
- Spontaneous activity of the uterine muscle in rats was inhibited in vitro by the sodium salts of dicarboxylic acids.
- Total abolition of mechanical events was observed at a dodecanedioic acid concentration of 0.024 M.
- The intensity of this effect decreased in the order C12 > C10 > C9 > C6 dicarboxylic acid:
0.024 M - 0.032 M - 0.040 M - 0.064 M.
- A 50 % decrease in amplitude and frequency of spontneous contraction waves was observed at
0.009 M / 0.016 M / 0.033 M - 0.038 M for C12 / C10 / C9 / C6 dicarboxylic acid.
- Activity of the uterine muscle induced by administration of acetylcholine, oxytocin or prostaglandins (PGF2a) was antagonized by
these salts. The order of reactivity was also C12 > C10 > C9 > C6.
- In general, inhibition of induced contractions required higher dicarboxylic acid concentrations than inhibition of spontaneous
contractions.
- The results suggested that the inhibitory effects on smooth muscle could be
due to a cellular membrane hyperpolarization.
Applicant's summary and conclusion
- Conclusions:
- In vitro effects were noted at very high concentration of concentration of 24 mmolar.
- Executive summary:
The influence of the sodium salt of some dicarboxylic acids (adipic acid, C6; azelaic acid, C9; sebacic acid, C10; dodecandioic acid, C12) on both spontaneous and evoked activity of uterine horn of rats has been studied in vitro. Spontaneous activity of uterine muscle was inhibited by dicarboxylic salts (DS) causing the total abolition of mechanical events at concentrations of 64 x 10(-3) M-C6, 40 x 10(-3) M-C9, 32 x 10(-3) M-C10 and 24 x 10(-3) M-C12. Dicarboxylic salts antagonized the maximal isometric contraction of the uterine horn induced by administration of acetylcholine, oxytocin or prostaglandins (PGF2 alpha). The amount of antagonism was dependent upon the concentration of DS used. Dicarboxylic salt showed an aspecific inhibitory effect on the uterine horn which progressively increased with their chain length (C12 greater than C10 greater than C9 greater than C6). The results suggested that the inhibitory effects of DS on smooth muscle could be due to a cellular membrane hyperpolarization.
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