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Diss Factsheets

Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
other: health surveillance
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1989

Materials and methods

Study type:
medical monitoring
Endpoint addressed:
skin irritation / corrosion
repeated dose toxicity: inhalation
Principles of method if other than guideline:
Regular medical examinations
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-furaldehyde
EC Number:
202-627-7
EC Name:
2-furaldehyde
Cas Number:
98-01-1
Molecular formula:
C5H4O2
IUPAC Name:
2-furaldehyde
Constituent 2
Chemical structure
Reference substance name:
Furfuryl alcohol
EC Number:
202-626-1
EC Name:
Furfuryl alcohol
Cas Number:
98-00-0
Molecular formula:
C5H6O2
IUPAC Name:
2-furylmethanol

Method

Type of population:
occupational
Ethical approval:
not specified
Details on study design:
Medical centre Sevnica, Slovenia performed regular medical examinations of Jugotanin employees from 1979 to 1989. Examined employees also included those exposed to furfural. The results of examinations performed on seven employees that were followed for ten years. The emphasis of preventive medical examinations was on personal history, precise physical examination and laboratory examinations.
Employees were born between 1942 and 1964. They were healthy and capable for work at the time of beginning their employment.
The examined employees had their spirometric, ECG and blood pressure parameters in the framework of reference values.

Results and discussion

Results:
During preventive health examinations, none of the employees complained about any problems that would be related to work burdens and noxious aspects of their jobs.
There were no fundamental deviations in physical status. None of the employees had any skin changes that would be a consequence of daily contact with chemicals.
Laboratory examinations did not show any pathologic deviations (spirometric, ECG, and blood pressure parameters) and the liver tests were in the limits of reference values.

Applicant's summary and conclusion

Conclusions:
None of the examined employees was diagnosed with health damages that would be related to furfural exposure.
Executive summary:

Medical centre Sevnica, Slovenia performed regular medical examinations of Jugotanin employees from 1979 to 1989.  Examined employees also included those exposed to furfural.  The results of examinations performed on seven employees that were followed for ten years are in the appendix.  The emphasis of preventive medical examinations was on personal history, precise physical examination and laboratory examinations.

Employees were born between 1942 and 1964.  They were healthy and capable for work at the time of beginning their employment.  During preventive health examinations, none of the employees complained about any problems that would be related to work burdens and noxious aspects of their jobs.

There were no fundamental deviations in physical status. None of the employees had any skin changes that would be a consequence of daily contact with chemicals. Breathing functions and cardiovascular systems of all the examinees were without pathological deviations.  There were no peculiarities in any of the body organ systems as well.

One of the employees was diagnosed with Duyputren's contracture, two of the employees were suspected of excessive alcohol consumption which, however, was not confirmed with laboratory tests.

The examined employees had their spirometric, ECG, and blood pressure parameters in the framework of reference values.

Laboratory examinations did not show any pathologic deviations, and the liver tests were in the limits of reference values.

None of the examined employees was diagnosed with health damages that would be related to furfural exposure.