Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-627-7 | CAS number: 98-01-1
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The key endpoint is the sludge respiration inhibition EC50 of 760 mg/L.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 760 mg/L
Additional information
One study according to OECD 209 (Volskay & Grady, 1988) and one study with Pseudomonas putida (Bringmann & Kuehn, 1976) are available. The RAR (2008) also summarises data available for flagellated protozoa (Bringmann & Kuehn, 1980).
Two studies are available with V. fischeri and added as supporting information.
According to the RAR (2008), data for both bacteria and protozoa should be taken into account when deriving a PNEC for micro-organisms.
However, this is restricted to ciliated protozoa, constituting the most important class of protozoa in sewage treatment plants (STPs) . The protozoa tested were all flagellates rather than ciliated protozoa and therefore the PNEC derivation is based on data for bacteria, as concluded in the RAR (2008).
Taking the sludge respiration inhibition test EC50 of 760 mg/l with an AF of 100 gives the most conservative PNEC which is therefore used in this assessment, in concurrence with the RAR (2008).
Additional reference:
Bringmann, G and R Kühn, 1980. Bestimmung der biologischen Schadwirkung wassergefährender Stoffe gegen Protozoa (III. Saprozoische Flagellaten). Z. Wasser Abwasser Forsch 13, no.5, pp 170-173.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
