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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

A weight of evidence approach has been used to conclude on the short-term toxicity to fish: Short-term LC50 values for freshwater fish range from 10.5 to 29 mg/L

From experimental studies the most conservative study has been selected: LC 50= 10.5mg/L determined in a 14 days test.

This value is considered the most reliable LC 50 as it was based on mean measured concentration annd due to the prolonged exposure period (14d), toxicity is not underestimated. Furthermore the LC 50 of 13.21 mg/L form the OECD 236, 96h is in line with this result.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
10.5 mg/L

Additional information

As reviewed in the RAR (2008), short-term LC50 values for freshwater fish range from 10.5 to 32 mg/L ( Deneer et al., 1988; Verschueren, 1983; Turnbull et al., 1954; Wallen et al., 1957). Juhnke & Luedemann (1978) also report an LC50 in this range i.e. 29 mg/L.

Although the LC50 value from the study by Deneer et al (1988) was determined in a 14-day test, this value is considered the most reliable LC50 as it was based on mean measured concentrations. Furthermore, due to the prolonged exposure period, toxicity is not underestimated.


Turnbull, H, JG DeMann, RF Weston, 1954. Toxicity of various refinery materials to fresh water fish, Ind. Eng., 46 (2), 324-333

Verschueren K (1983) Handbook of environmental data on organic chemicals, 2nd edition, Van Nostrand Reinolds, New York.

Wallen, IE, W.C Greer, R. Lasater, 1957. Toxicity to Gambusia affinis of certain pure chemicals in turbid waters. Sewage Ind. Wastes, 29 (6), 695-711.