Registration Dossier
Registration Dossier
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EC number: 939-265-0 | CAS number: 90583-18-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
- Reference Type:
- secondary source
- Title:
- SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
- Author:
- OECD
- Year:
- 2 007
- Bibliographic source:
- UNEP Publications
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- partly only limited information available (e.g environmental conditions of animals, details on test substance)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 90583-18-9 (purity 40.9-42%)
- IUPAC Name:
- 90583-18-9 (purity 40.9-42%)
- Details on test material:
- - Name of test material (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 40.9-42% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Kleinrusse Chbb:HM
Test system
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- Concentration: 25% a.i.
Amount applied: 0.1 mL - Duration of treatment / exposure:
- n.a.
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- Comment: not rinsed
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- other: mean of all 4 animals
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 21 days in one animal (score 1). Effects in the other 3 animals were fully reversible within 10 days.
- Irritation parameter:
- iris score
- Basis:
- other: mean of all 4 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- other: mean of all 4 animals
- Time point:
- 24/48/72 h
- Score:
- 2.8
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 21 days in one animal (score 1). Effects in the other 3 animals were fully reversible within 14 days.
- Irritation parameter:
- chemosis score
- Basis:
- other: mean of all 4 animals
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
Any other information on results incl. tables
Cornea
time (hrs) time (days)
1 6 24 48 72 7 21
mean A 0.75 1 1 1 1 0.5 0.25
mean B 0.75 2 4 2.75 2.5 0.75 0.25
A = cloudiness grade
B = cloudiness surface
Cornea (0.5 % aqueous fluorescein): mean 93.75 / 6.25 after 24 hrs / 21 days
Conjunctivae
time (hrs) time (days)
1 6 24 48 72 7 21
mean A 1.5 1.75 3 3 2.5 1.25 0.25
mean B 1 1.25 1 0.5 0.5 0 0
mean C 3 3 2.75 2.75 2.25 1.25 0.25
A = erythema
B = chemosis
C = exsudation
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information R36; classification of R41 is not justified at 25% a.i. Criteria used for interpretation of results: EU
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