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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1987
Report Date:
1987
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
yes
Remarks:
partly only limited information available (e.g environmental conditions of animals, details on test substance)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 40.9-42% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data

Test animals / tissue source

Species:
rabbit
Strain:
other: Kleinrusse Chbb:HM

Test system

Vehicle:
water
Controls:
not required
Amount / concentration applied:
Concentration: 25% a.i.
Amount applied: 0.1 mL
Duration of treatment / exposure:
n.a.
Observation period (in vivo):
21 days
Number of animals or in vitro replicates:
4
Details on study design:
Comment: not rinsed

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24+48+72 h
Score:
1
Max. score:
4
Reversibility:
not fully reversible within: 21 days in one animal (score 1). Effects in the other 3 animals were fully reversible within 10 days.
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24+48+72 h
Score:
0
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24+48+72 h
Score:
2.8
Max. score:
3
Reversibility:
not fully reversible within: 21 days in one animal (score 1). Effects in the other 3 animals were fully reversible within 14 days.
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24+48+72 h
Score:
0.7
Max. score:
4
Reversibility:
fully reversible within: 7 days

Any other information on results incl. tables

Cornea

                  time (hrs)                 time (days)
           1      6    24    48      72     7       21
mean A     0.75   1    1     1       1      0.5     0.25
mean B     0.75   2    4     2.75    2.5    0.75    0.25

A = cloudiness grade
B = cloudiness surface

Cornea (0.5 % aqueous fluorescein): mean 93.75 / 6.25 after 24 hrs / 21  days


Conjunctivae

           time (hrs)                           time (days)
           1      6       24      48     72     7     21
mean A     1.5    1.75    3       3      2.5    1.25  0.25
mean B     1      1.25    1       0.5    0.5    0     0
mean C     3      3       2.75    2.75   2.25   1.25  0.25

A = erythema
B = chemosis
C = exsudation

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information R36; classification of R41 is not justified at 25% a.i. Criteria used for interpretation of results: EU