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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1987
Reference Type:
study report
Title:
Unnamed
Year:
1999
Reference Type:
secondary source
Title:
SIDS Category of Alkyl sulfates, Alkane sulfonates and Alpha-olefin sulfonates
Author:
OECD
Year:
2007
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
The study was performed under occlusive conditions. No data on vehicle availabe.
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): trade name
- Physical state: No data
- Analytical purity: 40.9-42% a.i.
- Lot/batch No.: No data
- Storage condition of test material: No data

Test animals

Species:
rabbit
Strain:
other: Kleinrusse Chbb:HM

Test system

Type of coverage:
occlusive
Vehicle:
not specified
Controls:
not required
Amount / concentration applied:
Concentration: 25% a.i.
Amount applied: 0.5 mL
Duration of treatment / exposure:
4 hours
Observation period:
21 days
Number of animals:
5

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24+48+72 h
Score:
3.7
Max. score:
4
Reversibility:
fully reversible
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24+48+72 h
Score:
2.1
Max. score:
4
Reversibility:
fully reversible

Any other information on results incl. tables

time (hrs)                        time (days)
           1      24      48      72         7     10    14
mean E     1.8    3.6     3.8     3.6        2.8   1.8   0
mean O     0      1.8     2.4     2.2        1.8   1.4   0

E = erythema
O = oedema

Reversibility: yes

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU