Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 939-265-0 | CAS number: 90583-18-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP Guideline study According to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 bis (Acute Oral Toxicity - Fixed Dose Procedure)
- Deviations:
- yes
- Remarks:
- lack on details of test substance within the study report. Missing details were however received by the sponsor.
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Sulfuric acid, mono-C12-14-alkyl esters, sodium salts
- EC Number:
- 287-809-4
- EC Name:
- Sulfuric acid, mono-C12-14-alkyl esters, sodium salts
- Cas Number:
- 85586-07-8
- Molecular formula:
- C12-14H25-29SO4Na
- IUPAC Name:
- Sulfuric acid, C12-14-alkyl (even numbered) esters, sodium salts
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- According to guideline.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All male and one female animal treated at 2000 mg/kg bw died in the course of the first day of the study.
- Clinical signs:
- other: At 2000 mg/kg bw: All animals showed hunched back, decrease in motor activity, ataxia and pallor. In addition the males also presented piloerection, and the females hypotonia. At 500 mg/kg bw: No clinical signs
- Gross pathology:
- One male of the 2000 mg/kg bw dose group showed hemoperitoneum, gastric and small intestine mucous membranes very congested, and the inside of this organs with bloody looking liquid.
One female of the 2000 mg/kg bw dose group showed dilation of the whole of the small and cecum intestines, without apparent lesions.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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