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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.59 mg/L
Assessment factor:
1 000
PNEC freshwater (intermittent releases):
5.9 mg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.059 mg/L
Assessment factor:
10 000

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
105 mg/L
Assessment factor:
10

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.482 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.048 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.112 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

The following reliable data is available for environmental classification of titanium tetraisopropanolate:

Acute Aquatic Toxicity:

Short-term toxicity to fish:

96-h LC50 (mortality) to Rasbora heteromorpha; 4200 mg/L based on nominal concentrations (read-across from IPA; Tooby & Hursey 1975)

Short term toxicity to invertebrates:

48-hour EC50 (immobilisation) to Daphnia magna; 590 mg IPA/l (95 % CI, 570 to 610 mg IPA/l) based on the measured (0-hour) concentrations. (OECD 202; Goodband 2010)

48-hour EC50 (immobilisation) to Daphnia magna; 700 mg/l (95% Cl, 680 to 720 mg /l based on the equivalent test item concentrations. (OECD 202; Goodband 2010)

Toxicity to algae:

The 72h-EC50 (growth rate) to Desmodesmus subspicatus; >820 mg /l based on measured IPA concentrations (OECD 201; Vryenhoef & Mullee 2010)

The 72h-NOEC (growth rate) to Desmodesmus subspicatus; 201 mg /l based on measured IPA concentrations (OECD 201; Vryenhoef & Mullee 2010)

The 72h-EC50 (growth rate) to Desmodesmus subspicatus; >960 mg /l based on equivalent test item concentrations (OECD 201; Vryenhoef & Mullee 2010)

The 72h-NOEC (growth rate) to Desmodesmus subspicatus; 237 mg /l based on equivalent test item concentrations (OECD 201; Vryenhoef & Mullee 2010)

Conclusion: No acute aquatic toxicity as the lowest of the available toxicity value is > 100 mg/l.  

Degradation:  

Abiotic degradation (hydrolysis): Hydrolytically unstable, Half-life less than 3 minutes (OECD 111)

Main organic decomposition product (IPA) is non-toxic to aquatic environment and readily biodegradable (> 70 % at 20-d biodegradation, Price et al. 1974) The aquatic toxicity values (EC50/LC50) of the main degradation product (IPA) based on the literature are:

Scenedesmus quadricauda, 1800 mg/l in freshwater

Daphnia magna, 6850 mg/l in freshwater

Daphnia magna, >10 000 mg/l in freshwater

Artemia salina, >10000 mg/l in artificial sea water

Pimephales promelas, 9640 mg/L in fresh water

Pimephales promelas,11130 mg/L in lake superior water

Rasbora heteromorpha, 4200 mg/L in fresh water

Conclusion: rapidly degradable.  

Bioaccumulation:

Log Kow for the main degradation product (IPA) is 0.05. Not possible to determine for the target substance because of rapid hydrolysis.  

Conclusion: No chronic aquatic toxicity as the lowest available toxicity value is > 100 mg/l, substance is rapidly degradable, and the degradation products have low potential for bioconcentration and bioaccumulation.  

Environmental classification:

In accordance with EC Regulation 1272/2008 (CLP):

Not classified as hazardous

In accordance with DSD (Directive 67/548/EEC):

Not classified as hazardous