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Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

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Administrative data

Link to relevant study record(s)

Description of key information

Testing is not scientifically justified as substance is hydrolytically unstable. The most relevant degradation product (IPA) is readily biodegradable, and this information is used in CSA when relevant (see section 9&10 of CSR). One of the non-hazardous degradation products (TiO2) is inorganic and insoluble and therefore not relevant to be considered in CSA. 

Key value for chemical safety assessment

Biodegradation in water:
readily biodegradable

Additional information

Testing of biodegradability of titanium tetraisopropanolate is not scientifically justified as it is hydrolytically unstable. When this substance comes in contact with water or moisture, a complete hydrolysis will take place with no significant reaction products other than isopropanol (IPA) and hydrated titanium dioxides (key study on hydrolysis OECD 111). In addition, biodegradability testing is not necessary as all the decomposition products have been identified. The most relevant degradation product (IPA) is also known to non-toxic to aquatic environment and readily biodegradable (> 70 % at 20-d biodegradation, Price et al. 1974). The other environmentally non-hazardous degradation product (TiO2) is inorganic and insoluble and therefore not relevant for this endpoint. As the rapid hydrolysis is the driving force for the fate and pathways of this substance, this abiotic degradation can be used to demonstrate fast degradation of this substance for the purposes of C&L.