Registration Dossier
Registration Dossier
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EC number: 208-909-6 | CAS number: 546-68-9
Endpoint summary
Administrative data
Description of key information
Additional information
Testing of biodegradability in water is not scientifically justified as titanium tetraisopropanolate is hydrolytically unstable. Key study without restrictions on hydrolysis OECD 111 demonstrates that a complete hydrolysis (half-life < 3minutes) will take place with no significant reaction products other than isopropyl alcohol (IPA) and hydrated titanium dioxides.
In addition, biodegradability testing is not necessary to be tested for this substance as all the decomposition products have been identified. The most relevant degradation product (IPA) is also known to be readily biodegradable (> 70 % at 20-d biodegradation, Price et al. 1974). IPA is not toxic to aquatic environment and has no adsorption or bioaccumulation potential since it has a low log Kow value 0.05 (< 3). The other non-hazardous degradation product (TiO2) of this substance is inorganic and insoluble and therefore not relevant to be considered further in CSA. Ti compounds are not expected to bioconcentrate in soils, sediments or aquatic organisms (HSDB 2012).
Because this substance is highly water reactive use of water is avoided in the use applications, and direct exposure of the aquatic compartment is unlikely (see sections 9&10 of CSR). Only, when the target substance is used as a catalyst in industrial esterification processes, water is used to remove the catalyst from the process. The decomposition of the titanate catalyst will take place, and IPA and TiO2 are released to water compartment. Therefore, it is justified to use the biodegradability of the main degradation product (IPA) in the exposure assessment when relevant (see sections 9&10 of CSR).
As the rapid hydrolysis is the driving force for the fate and pathways of this substance, this abiotic degradation can be used to demonstrate fast degradation for the purposes of C&L.
Based on these facts, CSA does not indicate the need to investigate further the biodegradation in water, soil or sediments.
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