Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-291-6 | CAS number: 56-84-8
Carcinogenicity
Administrative data
Description of key information
Human cells normally handle large quantities of the dicarboxylic amino acid L-aspartic acid, which is an essential part of normal cellular function. Aspartate enters the Krebs cycle and the urea cycle. Protein in the diet is digested in the gut and the amino acids or small peptides are absorbed. L-aspartate is absorbed from the intestinal lumen by an active transport process. Metabolism occurs during the absorption process of free and protein bound L-aspartate, by transamination, resulting in oxaloacetate, thereby reducing the available amount of L-aspartate in the portal blood. As L-aspartic acid (and L-aspartate) is regarded as “inherently safe” by the FDA it is also added to the diet by the food industry. Since L-aspartic acid will be readily metabolized, is a part of the usual biochemistry of the body, and the mutagenicity tests are negative, there is no indication that L-Aspartic acid has any carcinogenic activity.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
