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EC number: 500-040-3
CAS number: 25686-28-6
Dose level (mg/l)
Mortalities (male/female) at day
* Day 0 is day of exposure
LC50: 0.490 mg/l (95% confidence limits: 0.376 and 0.638
mg/l); with the HPLC analysis the values are 0.456 mg/l (0.054 and 3.822
Results of the test group B was rejected because the
values were completely out of range (zero mortality) and the exposure
appeared too low (mean: 167 mg/m3).
On analysis the hair of the animals, the results were:
the amount of non-extractable pMDI components with free NCO groups
ranged from 170 to 340 µg per g hair (or from 250 to 426 µg per animal).
The amount of monomeric MDI on the hair ranged from 12 to 34 µg per g
hair or from 16 to 50 µg per animal). No MDA could be detected in any
hair samples (detection limit: 5 µg MDA per g hair). No grooming
activity was observed in any of the rats. The mean body weight, measured
in a group of 5 animals, was reduced by about 30 % after 4 exposure. No
death occurred, but the animals showed serious clinical signs especially
after the 2nd exposure period laboured respiration that did not
disappear during the non-exposure period but worsened during the
following exposures. At the end of the 5th exposure the animals showed
mouth breathing and were in very bad conditions. The animals did not eat
or drink during the last 2 days of the study. Results: only very small
amounts of pMDI components could be recovered from the fur of the
animals. Ingestion (via grooming) was not expected to contribute
significantly to the effects seen in this and aforementioned inhalation
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