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EC number: 500-040-3 | CAS number: 25686-28-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Oxidising properties
Administrative data
Link to relevant study record(s)
- Endpoint:
- oxidising liquids
- Type of information:
- other: exemption statement
- Adequacy of study:
- key study
- Study period:
- Start date of the experimental work: 12 June 2009 and Completion date of the experimental work: 02 July 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Conducted at a GLP accredited laboratory
- Justification for type of information:
- Experimental techniques are available for the classification of a substance or preparation as oxidising. These are described in EC Test A21. However, Test A21 need not be carried out when examination of the structural formula establishes beyond reasonable doubt that the substance has no oxidising properties. The supplement to the A21 method describes situations in which experimental assessment of oxidising properties is not necessary.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Exemption statement
- GLP compliance:
- no
- Key result
- Parameter:
- other: Expert statement
- Remarks on result:
- not measured/tested
- Remarks:
- The material meets all criteria for exemption from testing and has a structure not at all conducive with that required to exhibit oxidising tendencies.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is considered as not oxidising and should not be subjected to experimental testing. The material meets all criteria for exemption from testing and has a structure not at all conducive with that required to exhibit oxidising tendencies.
Reference
Assessment of Oxidising Properties of 4,4'-Methylenediphenyl diisocyanate, oligomers
Examination of the structural formula indicates:
• The molecule does not contain any functional groups listed in Table 17.3. Although this list is not exhaustive, this is a significant observation as most commonly occurring oxidising functional groups are contained within the list.
• According to the two criteria quoted, oxidising properties can exist when:
o the electronegative atoms which are present constitute a high proportion of the molecule and are bound to elements in a high oxidation state In the case of 4,4'-Methylenediphenyl diisocyanate, oligomerst he proportion of electronegative atoms in the molecule is low. In addition, none of the oxygen atoms are bound to elements of a high oxidation state. All of the oxygen atoms are bound to carbon.
o the electronegative atoms are bonded to each other or to other electronegative elements such as iodine, nitrogen, sulphur or phosphorus. In the case of the test substance the electronegative atoms are not bound to one another, nor to any other electronegative elements.
o Assessment against these two criteria indicates strongly that the molecule will not have oxidising properties.
In every respect of the oxidising properties exemption procedure, the test substance does not show any evidence of possessing oxidising properties.
On the basis of this exercise, the material should be considered as not oxidising and should not be subjected to experimental testing. The material meets all criteria for exemption from testing and has a structure not at all conducive with that required to exhibit oxidising tendencies.
Description of key information
The test item is considered as not oxidising and should not be subjected to experimental testing. The material meets all criteria for exemption from testing and has a structure not at all conducive with that required to exhibit oxidising tendencies.
Key value for chemical safety assessment
- Oxidising properties:
- non oxidising
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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