Registration Dossier
Registration Dossier
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EC number: 931-216-1 | CAS number: 1335202-95-3
Endpoint summary
Administrative data
Description of key information
Low bioaccumulation potential (BCF = 13 L/kg, read-across from DOCMAC; BCF = 70.8 L/kg, EPIWIN v4.11, BCFBAF v3.01)
Additional information
No experimental data on bioaccumulation is available for the target substance oleic acid-based TEA-Esterquat. However, data from the structurally related substance DODMAC (Dimethyldioctadecylammonium chloride) are provided. A justification for read-across is attached in the target record.
Juvenile fish (Pimephales promelas) were exposed to the structurally similar substance DODMAC for 24 h under flow-through conditions, followed by a depuration period of 72 h. A BCF of 104 L/kg is calculated based on the uptake rate constant (k1) of 1.35 mg/g·h and the depuration rate constant (k2) of 0.013 mg/g·h (Versteeg & Shorter, 1992).
The measured BCF values for similar substances (DODMAC, DHTDMAC (Dihydrogenated Tallow Alkyl Dimethyl Ammonium Chloride)) are 12-32 (BUA-Report 191, 1995) and 13-256 (EU RAR, 2002). The conclusion for DODMAC was “bioaccumulation is indicated, but it is assumed that it is low under environmental conditions. A BCF of 13 L/kg is used in the risk assessment…” (EU RAR, 2009).
This is further supported by a QSAR calculation that yielded a calculated BCF value for C18 and C18 unsatd. TEA-Esterquat of 70.79 L/kg (EPIWIN v4.11, BCFBAF v3.01). As this QSAR model does not include metabolism, it can be considered a conservative estimate of BCF.
The low bioavailability of the substance (due to rapid and strong sorption to negatively charged surfaces in the aquatic environment) in combination with the rapid (bio)degradation of the bioavailable fraction (mainly due to the hydrolysis of the ester bond), make high bioconcentration factors for the substance even more improbable (Comberet al., 2003 in Hera, 2008).
For the target substance oleic acid-based TEA-Esterquat a BCF of the same order of magnitude and not higher than DODMAC is to be expected. The above information is considered as sufficient to support the conclusion that the bioaccumulation potential of oleic acid-based TEA-Esterquat is expected to be low.
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