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Toxicological information

Toxicity to reproduction

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Administrative data

Endpoint:
toxicity to reproduction
Remarks:
other: Expert evaluation; review
Type of information:
other: Reviews
Adequacy of study:
supporting study
Reliability:
other: Reviews
Rationale for reliability incl. deficiencies:
other: Published conclusions by different expert groups

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
OECD/SIDS. Screening Information Data Set (SIDS) of OECD High Production Volume Chemicals Programme, CAS Number 37971-36-1
Author:
OECD/SIDS
Year:
1994
Bibliographic source:
UNEP Publications
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1994

Materials and methods

Test material

Constituent 1
Reference substance name:
37971-39-1
IUPAC Name:
37971-39-1

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

open allclose all
Dose descriptor:
other: Review on all available data
Basis for effect level:
other: see 'Remark'
Remarks on result:
not measured/tested
Remarks:
Effect level not specified Generation not specified (migrated information)
Dose descriptor:
other: Review on all available data
Basis for effect level:
other: BUA concluded that 2 -phosphono-1,2,4 -butanetricarboxylic acid has no toxic potential and no risk to humans could be deduced.
Remarks on result:
not measured/tested
Remarks:
Effect level not specified Generation not specified (migrated information)

Overall reproductive toxicity

Reproductive effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

OECD/SIDS concluded: "The available information on toxicity gave no evidence of damage in doses up to 375 mg/kg body weight. There is no evidence of embryo-toxicity, teratogenicity or genotxicity...Based on the available data on toxicity and the data on occupational exposure and exposure of the general population, 2 -phosphono-1,2,4 -butanetricarboxylic acid is of low concern."

BUA concluded that 2 -phosphono-1,2,4 -butanetricarboxylic acid has no toxic potential and no risk to humans could be deduced.