Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-733-5 | CAS number: 37971-36-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-11-03 to 1993-11-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: "Prolonged Toxicity Study with Daphnia magna: Effects on Reproduction" (proposal for an update of OECD guideline 202, Part II; Draft 6/5/1991)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- yes
- Remarks:
- the light intensity was slightly too high (25 instead of max. 20 µE/m2*s). TOC/ COD was not determined. CSB was determined.
- Principles of method if other than guideline:
- Compared with OECD 211, adopted in 2008): the light intensity was slightly too high (25 instead of max. 20 µE/m2*s).
TOC/ COD was not determined.
CSB was determined. - GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The test concentrations were analysed at t= 0h at the start of the experiment (1993-11-03) and after 48h after start of the experiment.
After renewal of the medium at the third day (1993-11-05) of the experiment the test concentrations were analysed at t= 0h and after 72h after renewal of the medium. - Vehicle:
- no
- Details on test solutions:
- NA
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Daphnia magna Straus
- parthenogenetic females- Source: West-Aquarium (Bad Lauterberg; Germany)
- Strain: clone breeding of the Federal Health Office, Berlin
- Source: Laborzucht der Bayer AG, Leverkusen (in-house breeding, Bayer AG)
- Age: 6 - 24 hours - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Post exposure observation period:
- NA
- Hardness:
- Not indicated
- Test temperature:
- ca. 20°C +/-2°C; per single test: 20°C +/-1°C
- pH:
- Controls: 7.6 - 8.1
1000 mg/L: 7.9-8.6 - Dissolved oxygen:
- Test vessels containing controls (%): 98.5-121.2
Test vessels containing 1000 mg/L (%): 100.2-129.1 - Salinity:
- Not indicated
- Nominal and measured concentrations:
- Nominal concentrations in mg/L.: 10; 31.6; 100; 316; 1000
Measured concentrations in mg/L: 10-11; 31-34; 99-109; 318-337; 991-1159 - Details on test conditions:
- TEST SYSTEM
- Photoperiod (hrs dark / hrs light): 8 / 16 hours rhythm
- Light intensity: ca.25 µE/m2*s; 1700 Lux
- Test medium:100 mL, non-aerated
- Vehicle: no
No. of organisms per vessel:
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 10
- No. of vessels per control (replicates): 10
Feed: algae "Scenedesmus subspicatus" - Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 071 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- immobilisation
- Duration:
- 21 d
- Dose descriptor:
- EC50
- Effect conc.:
- > 329 - < 1 071 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 104 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: DUNNETT-TEST
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 329 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: DUNNETT-TEST
- Details on results:
- NA
- Results with reference substance (positive control):
- NA
- Reported statistics and error estimates:
- The DUNETT test was performed for NOEC (reproduction) and LOEC (reproduction).
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC 50 (immobilisation, 21d): > 1071 mg/L
EC 50 (reproduction, 21d): > 329 - < 1071 mg/L
NOEC (reproduction, 21d): 104 mg/L
LOEC (reproduction, 21d): 329 mg/L - Executive summary:
A prolonged toxicity study in Daphnia magna was performed over 21 days.
The respective effects on reproduction (NOEC, LOEC, EC50) and mobility were determined (EC50):
EC 50 (immobilisation, 21d): > 1071 mg/L
EC 50 (reproduction, 21d): > 329 - < 1071 mg/L
NOEC (reproduction, 21d): 104 mg/L
LOEC (reproduction, 21d): 329 mg/L
Reference
No remarks.
Description of key information
A prolonged toxicity study in Daphnia magna was performed over 21 days.
The respective effects on reproduction (NOEC, LOEC, EC50) and mobility were determined (EC50):
EC 50 (immobilisation, 21d): > 1071 mg/L
EC 50 (reproduction, 21d): > 329 - < 1071 mg/L
NOEC (reproduction, 21d): 104 mg/L
LOEC (reproduction, 21d): 329 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Remarks:
- reproduction
- Effect concentration:
- > 104 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
