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Toxicity to microorganisms

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Description of key information

Yoshioka et al. 1985 developed the test using Tetrahymena pyriformis in order to determine the toxicity of various chemicals. Pre-cultured T. pyriformis was exposed for 24 h at 30°C to DBP, and the number of T. pyriformis surviving were then counted. The concentration of the chemical, at which the proliferation of T. pyriformis was restricted to one-half of the blank test (EC50), was determined. The EC 50 for DBP was 2.2 mg/L.

Key value for chemical safety assessment

EC50 for microorganisms:
2.2 mg/L

Additional information

Jonsson, S., and Baun, A., 2003 studied the toxicity of various esters to crustacean, green alga nad bacterium. Static test with saltwater bacteriaVibrio fisheriwas performed according to ISO standard method (11348 -3). The 15 min EC50 for dibutyl phthalate was established as more than 7.40 mg/L. The test cannot be used for the derivation of a PNECmicroorganisms that is relevant for a STP situation, as a saltwater species is used.

Tarkpea et al. (1986) studied using MICROTOX toxicity of Photobacterium phosphoreum. The 30 min EC50 was 10.9 mg/L.

The MICROTOX test cannot be used for the derivation of a PNECmicroorganisms that is relevant for a STP situation, as a saltwater species is used (EU RAR for DBP, 2004).

In the Pseudomonas putidatests (BASF AG, 1990) no effects of DBP were found even at concentrations above the water solubility of the substance. NOEC is more than 10 mg/L.

In the range between 19 and 2500 mg/L test substance approximately 20 % inhibition was measured. Respiration inhibition was greater than 20 %. 
    

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