Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-557-4 | CAS number: 84-74-2
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Timothy J. Ward and Robert L. Boeri, 1991 studied the early life stage toxicity of dibutyl phthalate (synonym: di-n-butyl phthalate) to the rainbow trout (Oncorhynchus mykiss) during a test conducted for 99 days.
Mean measured concentrations of test substance were 0.10, 0.19, 0.40, 0.84 and 1.7 mg/L, and these values were 71 to 85% of nominal values.
The total length and wet weight of rainbow trout after 99 days of exposure (the most sensitive exposure parameter) were significantly reduced in comparison to control at 0.19 mg/L DBP. The lowest observed effect concentration (LOEC) was 0.19 mg/L, and the no observed effect concentration (NOEC) was 0.10 mg/L DBP. The maximum acceptable toxicant concentration (MATC), express as the geometric mean of the LOEC and NOEC was 0.14 mg/L DBP.
The study is considered as reliable with acceptable restrictions.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 µg/L
Additional information
The IPCS document on DBP contains a few long-term toxicity studies with fish (IPCS/WHO, 1997). The lowest NOEC was observed in a 99-day test (60 days posthatch) with Oncorhynchus mykiss (Ward and Boerie, 1991). A measured value of 100 μg/l was established based on growth as the most sensitive endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
