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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Timothy J. Ward and Robert L. Boeri, 1991 studied the early life stage toxicity of dibutyl phthalate (synonym: di-n-butyl phthalate) to the rainbow trout (Oncorhynchus mykiss) during a test conducted for 99 days.
Mean measured concentrations of test substance were 0.10, 0.19, 0.40, 0.84 and 1.7 mg/L, and these values were 71 to 85% of nominal values.
The total length and wet weight of rainbow trout after 99 days of exposure (the most sensitive exposure parameter) were significantly reduced in comparison to control at 0.19 mg/L DBP. The lowest observed effect concentration (LOEC) was 0.19 mg/L, and the no observed effect concentration (NOEC) was 0.10 mg/L DBP. The maximum acceptable toxicant concentration (MATC), express as the geometric mean of the LOEC and NOEC was 0.14 mg/L DBP.
The study is considered as reliable with acceptable restrictions.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
100 µg/L

Additional information

The IPCS document on DBP contains a few long-term toxicity studies with fish (IPCS/WHO, 1997). The lowest NOEC was observed in a 99-day test (60 days posthatch) with Oncorhynchus mykiss (Ward and Boerie, 1991). A measured value of 100 μg/l was established based on growth as the most sensitive endpoint.