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EC number: 201-064-4
CAS number: 77-86-1
The acute dermal irritation study in rabbits was conducted to evaluate
the skin irritation potential of Tris Amino Ultra Pure. Under the
testing conditions of this study, the test substance Tris Amino Ultra
Pure showed no evidence of dermal irritation. Five hundred mg (0.5g) of
the test substance was made into a paste with a sufficient volume of
water and mixed with a glass rod. The resulting paste was applied to the
dose site and covered with a gauze pad of approximately 6 cm2 (2 x 3 cm
- 6ply). The patch was secured to the body of the animal by a
non-irritating semi-occlusive adhesive tape. After a 4-hour contact
period, the bandage was removed and the dose site was wiped with water
using clean towels. Three rabbits were treated at once. The degree of
irritation was evaluated and scored by Draize’s evaluation method at 1,
24, 48 and 72 hours post removal of the test patch. There were no
clinical signs of toxicity or pre-terminal deaths. There were no skin
reactions observed at any time point during the study.
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