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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

dermal absorption, other
expert statement
Type of information:
other: expert statement
Adequacy of study:
key study
Study period:
1 (reliable without restriction)

Data source

Reference Type:
other: expert statement
Report date:

Materials and methods

Results and discussion

Applicant's summary and conclusion

The absorption of lithium through skin is considered to be very poor. 10 % absorption was used for DNEL deduction representing a worst case.
Executive summary:

Expert statement: Due to the chemical properties of lithium hydroxide and lithium hydroxide monohydrate, the dermal absorption of these substances at non-corrosive concentrations is expected to be very poor. Based on (1) the hydrophilic character of these substances and (2) the barrier function of the stratum corneum against the respective ions, dermal absorption can practically be excluded. Similar to other lithium salts the acute dermal toxicity of non-corrosive concentrations is expected to be LD50 is > 2000 mg/kg bw as noted for of e.g. lithium carbonate. This also reflects the almost negligible skin penetration of inorganic lithium compounds. 10 % absorption was used for DNEL deduction. Thus, this presents a worst case.