Registration Dossier
Registration Dossier
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EC number: 215-183-4 | CAS number: 1310-65-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A semi-static Daphnia magna reproduction test was performed with lithium hydroxide monohydrate according to OECD Guideline No. 211. The NOEC for lithium hydroxide monohydrate determined on reproduction was 4.0 mg/L and the LOEC was 8.0 mg/L. Based on these data, the calculated NOEC for lithium hydroxide anhydrous was 2.3 mg/L and the LOEC 4.6 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 2.3 mg/L
Additional information
A semi-static Daphnia magna reproduction test was performed with lithium hydroxide monohydrate according to OECD Guideline 211. At this method Daphnia magna, aged lower or equal 24 h at the beginning of the test, are exposed to a range of lithium hydroxide monohydrate under defined conditions over a period of 21 days. The test item is a solid soluble in water and therefore, no solvent was used. The test solutions were prepared in a dilution series from a stock solution of 100 mg/L of the test item in culturing medium. In the definitive test the nominal concentrations were as follows: 0.25, 0.5, 1.0, 2.0, 4.0, 8.0 and 16.0 mg/L. Analysis of the test solutions for lithium confirmed that the test solutions were correctly dosed and stable during the exposure period (recoveries ranging from 95.5 to 102 % of nominal concentrations for the freshly prepared and aged test solutions). Therefore, the concentrations were reported as nominal concentrations. The test item lithium hydroxide monohydrate caused a statistically significant effect on live offspring of the Filial generation (F1) derived from the parent animals surviving at the end of the test at nominal test concentration of 8.0 mg lithium hydroxide monohydrate/L according to Dunnett`s test (p = 0.05). Therefore, the NOEC determined on reproduction was 4.0 mg/L and the LOEC was 8.0 mg/L. Based on these data, the calculated NOEC for lithium hydroxide anhydrous was 2.3 mg/L and the LOEC 4.6 mg/L.
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