Registration Dossier
Registration Dossier
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EC number: 234-685-4 | CAS number: 12023-91-5
Endpoint summary
Administrative data
Description of key information
Strontium ferrite has not proven to be
- irritant to the skin
- corrosive to the skin
- irritant to eyes
- corrosive to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation
The acute dermal irritation of strontium ferrite was assessed in a test according to OECD 404 and UN-GHS. No animal showed mean value ≥2.3 for erythema / eschar or for oedema. One animal showed barely perceptible erythema shortly after application which was fully reversible. No other effects were observed.
Based on the results, strontium ferrite can be considered as not irritant to skin and does not require labelling.
In-vitro testing for skin corrosion and skin irritation is not required.
Skin corrosion
Strontium ferrite was tested for skin corrosivity in an in-vitro study using EpiDerm as a human skin model in accordance with OECD 431. The test was conducted with a negative control (water) and a positive control (8 N KOH). Strontium ferrite proved to be non corrosive in this test.
Eye
In-vitro eye irritation (and in-vitro eye corrosion) was tested by using isolated chicken eyes. The test guideline was "OECD Guideline for the Testing of Chemicals: Isolated Chicken Eyes Test Method for Identifying Ocular Corrosives and Severe Irritants. Adopted: 7 Sep 2009" which follows OECD Guideline 438.
The test substance strontium ferrite as well as a positive control (sodium hydroxide) and a negative control (0.9 % sodium chloride saline) were applied to isolated chicken eyes. The endpoints evaluated were:
1. corneal opacity
2. fluorescein retention
3. adverse morphological effects.
For the test substance strontium ferrite, the mean maximum opacity score after treatment is 1.0 (Class II); the mean fluorescein retention score at 30 min after treatment is 0.8 (Class II). No adverse morphological effect was observed in all the seven ICEs during the observation period. He
nce, the test substance is not considered as ocular corrosive or severe irritant.For positive control substance, the mean maximum opacity score after treatment is 3.0 (Class IV); the mean fluorescein retention score at 30 min after treatment is 1.7 (Class III). The corneal opacity of all the three eyes was ≥2 at 30 min after treatment. Hence, the positive control substance is considered as ocular corrosive or severe irritant.
For negative control substance, the mean maximum opacity score after treatment is 1.0 (Class II); the mean fluorescein retention score at 30 min after treatment is 0.5 (Class I). Hence, the negative control substance is not considered as ocular corrosive or severe irritant.
Under the condition of the study strontium ferrite is not considered as ocular corrosive or severe irritant using Isolated Chicken Eye Test Method.
In-vivo eye irritation was tested according to OECD Guideline 405 and UN-GHS. Strontium ferrite was applied to the right eyes of rabbits each, the left eyes were left untreated serving as a negative control. Observation periods for both eyes of all animals were 1h, 24 h, 48h and 72 h.
The endpoints were evaluated:
- cornea score
- iris score
- conjunctivae score
- chemosis score.
At any time during the observation period, no severe eye lesions or continuing signs of severe pain or distress was observed in all animals. Although there were some slight redness (scored at 1) in conjunctivae in 2 animals right eye at 1 hr, and in the third animal right eye at 24 hrs; no animal showed conjunctival redness≥2. The slight redness was considered to be due to the mechanical abrasion because the redness disappeared after washing out the test substance.
Under the condition of this study, strontium ferrite is not considered as eye irritant.
Justification for classification or non-classification
Strontium ferrite does not show any irritating or corrosive properties towards both the skin and the eyes. Thus classification is not required.
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