Registration Dossier
Registration Dossier
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EC number: 234-685-4 | CAS number: 12023-91-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Key study: A toxicokinetic study according to OECD 417 was performed by using Wistar rats. 2000 mg/kg b.w. and 5000 mg/kg b.w. of the test substance strontium ferrite was applied to 20 animals each via the dermal route. Blood samples were taken 30 min, 2 h, 6 h, 10 h and 24 after the application period of 6 h.Blood concentration of strontium ferrite in each animal was below detection level (method: ICP-MS) at any sampling intervall with both doses.
The test substance was not detectable at all time points at both dose levels. Based on the above results, strontium ferrite was not detected in the blood after dermal route application. There was no significant absorption through dermal application. No other adverse effect was observed on all test animals during the study.
Medical case study: A 22 year-old schizophrenic man was brought to hospital after having ingested pulverized strontium ferrite from magnets. The strontium level in blood and urine was measured. The blood strontium level taken approximately 24 h after ingestion was 2900 µg/l. The urine strontium level collected approximately 48 h after ingestion was 15000 µg/l. This level decreased to 370 µg/l one week later. The reference range for urine is < 240 µg/l, the occupational threshold in USA 800 µg/l. One can conclude from this medical case study that strontium from strontium ferrite is excreted via urine in humans. The percentage of excretion was not determined.
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