Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 215-693-7 | CAS number: 1344-37-2 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77603.
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: Information from Risk Assessment Report
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information from the European Union Risk Assessment Report on Chromium compounds.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report CHROMIUM TRIOXIDE, SODIUM CHROMATE, SODIUM DICHROMATE, AMMONIUM DICHROMATE AND POTASSIUM DICHROMATE
- Author:
- European Union
- Year:
- 2 005
- Bibliographic source:
- 3rd Priority List, Volume 53
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Information from European Risk Assessment Report in which available information on skin sensitising properties of hexavalent chromium compounds was reviewed.
- GLP compliance:
- no
- Remarks:
- not applicable
- Type of study:
- other: Review based on different types of study
Test material
- Reference substance name:
- Chromium compounds
- IUPAC Name:
- Chromium compounds
- Test material form:
- other: not applicable
- Details on test material:
- Chromium trioxide, Sodium chromate, Sodium dichromate, Ammonium dichromate, Potassium dichromate
Constituent 1
In vivo test system
Test animals
- Species:
- other: review of available information
- Details on test animals and environmental conditions:
- not applicable
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: review of available information
- Vehicle:
- other: not applicable
- Concentration / amount:
- not applicable
Challengeopen allclose all
- Route:
- other: review of available information
- Vehicle:
- other: not applicable
- Concentration / amount:
- not applicable
- No. of animals per dose:
- not applicable
- Details on study design:
- not applicable
- Challenge controls:
- not applicable
- Positive control substance(s):
- not specified
- Remarks:
- not applicable
Results and discussion
- Positive control results:
- not applicable
Any other information on results incl. tables
Skin sensitization has been demonstrated in workers who were exposed to hexavalent Chromium compounds. Patch testing of contact dermatitis patients and other investigations of different occupational groups confirm skin sensitizing potential. Furthermore, available animal studies, including standard and modified guinea pig maximization tests and a mouse ear swelling test, confirm the skin sensitizing potential of hexavalent Chromium compounds.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In the European Union Risk Assessment Report on Chromium compounds, the available information on skin sensitisation potential is reviewed. Based on the available information from exposed workers and animals studies, Chromium compounds are considerd to be sensitising to the skin and should be classified as such.
- Executive summary:
In the European Union Risk Assessment Report (RAR) on Chromium trioxide, Sodium chromate, Sodium dichromate, Ammonium dichromate, and Potassium dichromate, the skin sensitizing potential of these Chromium compounds was reviewed. Skin sensitization has been demonstrated in workers who were exposed to hexavalent Chromium compounds. Patch testing of contact dermatitis patients and other investigations of different occupational groups confirm skin sensitizing potential. Furthermore, available animal studies, including standard and modified guinea pig maximization tests and a mouse ear swelling test, confirm the skin sensitizing potential of hexavalent Chromium compounds.
Based on the available information, Chromium compounds are considerd to be sensitising to the skin and should be classified as such.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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