Registration Dossier
Registration Dossier
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EC number: 246-495-9 | CAS number: 24851-98-7
Endpoint summary
Administrative data
Description of key information
Additional information
The substance is not classified as a « difficult test substance » according to the OECD Guidance document on aquatic toxicity testing of difficult substances and mixtures (OECD series on testing and assessment n° 23). The substance has been shown to be moderately soluble (561 mg/l at 20°C), not volatile (Vapor pressure < 0.01hPa, Henry’s law constant H < 0.01 Pa m3/mol), non-ionisable and stable in the aquatic tests conditions (t1/2 pH4 and pH 7 > 1 year, t1/2 pH9 = 7.8 days). Based on hydrolysis data and measured concentrations of the Daphnid chronic study it is very likely the substance did not degrade during the test at a pH around 7 at the concentrations used. Furthermore the low octanol/water partition coefficient (log Pow< 3.0) indicates that loss due to partitioning (adsorption to the test equipment or to the test organisms) is not significant. Therefore, no concerns due to the properties of the test substance occurred during the tests.
In the table below are summarized the results of aquatic toxicity studies performed:
Test guideline
|
Median lethal dose (mg/l) |
NOEC (72h) (mg/l) |
|
Fish Acute toxicity (OECD 203) |
LC50 (96h) |
18.2 |
|
Short term Toxicity to Daphnia (OECD 202) |
EC50 (48h) |
8.25 |
|
Algal Growth Inhibition Test (OECD 201) |
ErC50 (72h) |
45.9 |
11.7 |
|
Median lethal dose (mg/l) |
EC10 (21 days)* (mg/l) |
|
Daphnia magna reproduction Test (OECD 211) |
EC50 (48h) |
16.1 |
1.86 (reproduction) 2.01 (mortality) |
* See attached report "Hedione _Chronic toxicity study to Daphnia magna_final_10032014.pdf"
As the substance is ready biodegradable, the Log Pow is <3 and the chronic EC10 for algae and daphnids are >1 mg/L, it is therefore not classified as hazardous to the aquatic environment according to DSD (67/548/CEE) and CLP (1272/2008/CEE).
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