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EC number: 203-794-9 | CAS number: 110-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 5 March - 2 April 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed and documented study anaolgue to "Inhalation Hazard Test" OECD guideline 403. No LC50 derivable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 403, 5. Annex: Inhalation Hazard Test
- Deviations:
- yes
- Remarks:
- nose-only exposure
- GLP compliance:
- not specified
- Test type:
- other: Inhalation Hazard Test
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-dimethoxyethane
- EC Number:
- 203-794-9
- EC Name:
- 1,2-dimethoxyethane
- Cas Number:
- 110-71-4
- Molecular formula:
- C4H10O2
- IUPAC Name:
- 1,2-dimethoxyethane
- Details on test material:
- colorless, clear liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Test Animals
- Body weight: males 163-178 g, females 177-194 g
- Diet: Altromin 1324, ad libitum
- Water: community tap water, ad libitum
Environmental Conditions
- Housing: Macrolon cages with softwood bedding
-Temperature: 20 - 22°C
Study period: 5. March - 2. April 1981
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- clean air
- Details on inhalation exposure:
- Each rat was placed in a plastic tube, which were connected to the inhalation chamber (20 L volume). Exposure was by nose exclusively. Ethylene glycol dimethyl ether was applied to a vaporizer and continuously evaporated. The resulting test substance/air mixture was carried to the inhalation chambers using an air stream of 600 L/h. Ethylene glycol dimethyl ether consupmtion was determined by weighing before study start and at study termination.
Inhalation was monitored by an automatic system. Temperature, pressure, CO, CO2 and O2 were measured continuously.
Temperature: 20 - 22.5°C
Pressure: 996 - 1004 mbar
Exposure duration: 1, 3 and 6 h - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by weighing substance container before and after exposure
- Duration of exposure:
- >= 1 - <= 6 h
- Concentrations:
- Group 1: 240 mg/L (1 hour), 6 males, 6 females
Group 2: 240 mg/L (3 hours), 6 males, 6 females
Group 3: 200 mg/L (6 hours), 6 males, 6 females - No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopy - Statistics:
- None
Results and discussion
- Preliminary study:
- None
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- 200 mg/L air
- Exp. duration:
- 6 h
- Remarks on result:
- other: test substance saturated atmosphere
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 240 mg/L air
- Exp. duration:
- 1 h
- Remarks on result:
- other: test substance saturated atmosphere
- Mortality:
- Group 1: 0/12 animals (1 h, 240 mg/L)
Group 2: 11/12 animals (3 h, 240 mg/L)
Group 3: 12/12 animals (6 h, 200 mg/L) - Clinical signs:
- other: Group 1: Ataxia, salivation, irregular respiration; all symptoms were reversible within 24 hours Group 2: Ataxia, anesthesia, disturbance of equilibrium, ventral position, tremor, absence of reflexes, piloerection, red colored lacrimation, irregular respi
- Body weight:
- Group 1: reduction of body weight on Day 1 to 6 after exposure, Days 7 to 14 regular body weight gain
- Gross pathology:
- Group 1: no effects
Group 2 (survivng animal): no effects
Groups 2 and 3 (dead animals): stomach filled with white foam - Other findings:
- None
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information No LC50 derivable, substance was tested at excess concentration (saturated atmosphere) Criteria used for interpretation of results: expert judgment
- Conclusions:
- The LC0 of Ethylene glycol dimethyl ether after 1 h inhalation exposure is 240 mg/L.
The LC100 of Ethylene glycol dimethyl ether after 6h inhalation exposure is 200 mg/L. - Executive summary:
Three groups of 6 male and 6 female Wistar rats were exposed to a saturated Ethylene glycol dimethyl ether atmosphere at concentrations of 200 and 240 mg/L for 1 (group 1), 3 (group 2) and 6 (group 3) hours. All animals of group 1 (1 h, 240 mg/L) survived without irreversible clinical signs or macroscopic findings. Body weight was reduced during Day 1 to 6 after exposure. From Day 7 on the weight gain was regular (post exposure period: 14 days). In group 2 (3 h, 240 mg/L) 11 of 12 animals died and in group 3 (6 h, 200 mg/L) all animals died. Macroscopic abnormality observed in those animals which died was white foam in the stomach.
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