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EC number: 204-685-9 | CAS number: 124-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Rationale for reliability A published study but one which contains sufficient experimental detail to be able to judge it reliable for risk assessment purposes.
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolic studies with diethylene glycol monobutyl ether acetate (DGBA) in the rat
- Author:
- Deisinger PJ, Guest D
- Year:
- 1 989
- Bibliographic source:
- Xenobiotica, 19, 9, 981-9
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- To establish the rate of in vitro enzymic hydrolysis in the blood of rats of the substance to the parent glycol ether 2-(2-butoxyethoxy)ethanol.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethyl acetate
- EC Number:
- 204-685-9
- EC Name:
- 2-(2-butoxyethoxy)ethyl acetate
- Cas Number:
- 124-17-4
- Molecular formula:
- C10H20O4
- IUPAC Name:
- 2-(2-butoxyethoxy)ethyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Diethylene glycol monobutyl ether acetate (DGBA)
- Physical state: liquid
- Analytical purity: 95%
- Supplier: Kodak Laboratory CHemicals (ROchester, NY)
- Impurities (identity and concentrations): 2-(2-ethoxyethoxy)ethyl acetate, diethyl phthalate, methyl substituted DGBA.
- Radiochemical purity (if radiolabelling): 97.1%
- Specific activity (if radiolabelling): 0.951uCi/mole
- Locations of the label (if radiolabelling): no data
- Supplier: Wizard Laboratories (Davis, CA)
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Wilmington, MA
- Weight at study initiation: 200-250g
- Individual metabolism cages: yes/no
- Diet: Purina Chow 5002, ad libitum
- Water: ad libitum
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Toxicokinetic parameters:
- half-life 1st: 3 minutes
Any other information on results incl. tables
Metabolism of the substance in blood through hydrolysis to 2 -(2 -butoxyethoxy)ethanol (22BEE) was rapid. By 12 minutes the concentration of the 2 -(2 -butoxyethoxy)ethyl acetate was reduced by a mean of 94% to 0.2mM where it reached a plateau. Similarly the concentration of the metabolite 22BEE rose rapidly to a plateau of 4.1mM. No hydrolysis was seen in saline solution and no significant decrease in 22BEE concentration was seen when this was incubated in either blood or saline.
Applicant's summary and conclusion
- Conclusions:
- The hydrolysis of 2-(2-butoxyethoxy)ethyl acetate to the parent glycol ether 2-(2-butoxyethoxy)ethanol in blood is very rapid. This suggests that
data for the latter is likely to be a very good surrogate for the systemic toxicity of the former. - Executive summary:
In an in vitro study to establish the rate of in vitro metabolism of 2 -(2 -butoxyethoxy)ethyl acetate in the blood of rats to the parent glycol ether 2-(2-butoxyethoxy)ethanol, hydrolysis was found to be very rapid with a half life of approximately 3 minutes. This suggests that data for the latter is likely to be a very good surrogate for the systemic toxicity of the former.
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