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EC number: 204-685-9
CAS number: 124-17-4
Four studies are available in four different fish species. Of these,
three were conducted for the required period of 96hrs and all gave very
consistent answers. The study that showed the lowest value established
the lower end of an LC50 range as 50mg/l.
Two studies have been carried out using Daphnia magna. These indicate
that 2 -(2-butoxyethoxy)ethyl acetate is of low toxicity to
invertebrates. D magna is the preferred species for this trophic level.
One of the studies was not performed for the normally required 48hrs
(only 24hr studies), however it showed a slightly lower EC50 value and
is therefore selected as the key parameter. A correction for the shorter
test duration is not required as a test for the requisite period gave a
There is no toxicity data for algae available for 2 -(2
-butoxyethoxy)ethyl acetate. However, there is data available for a read
across substance 2 -butoxyethyl acetate whichi is sufficient to meet the
requirements of the end point. A read across justification is attached
as a separate document to chapter 13 of the IUCLID. This concludes that
the read across is both justified and likely to be conservative and
over-predict the toxicity of 2 -butoxyethyl acetate. Two experimentally
derived results for the latter are available, both showing relatively
low toxicity to the species. The study used as the key study shows the
lower of the two results and is to a modern protocol. It is deemed
reliable, although the available publication is not particularly
detailed. The data is sufficient to judge with confidence that the
substance is of low toxicity to algae. The data is also sufficient to
provide evidence that this trophic level does not provide the critical
NOEC for use in deriving the PNEC for the aquatic compartment so the
absence of accurate data for the target substance itself is of low
In a reliable micro-organism inhibition test using activated industrial
sludge, 2 -2(butoxyethoxy)ethyl acetate caused no inhibition of the
sludge respiration up to the maximum tested concentration of 1575mg/l.
There is no chronic toxicity data available for fish. For invertebrates,
a semi-static study carried out to an AFNOR protocol (similar to an OECD
guideline study but shorter duration), Ceriodaphnia Dubai were exposed
to 2 -(2 -butoxyethoxy)ethyl acetate for 7 days. An EC10 for
reproduction of 10.84mg/l was established.
Testing for toxicity to sedment and soil dwelling organisms is not
deemed scientifically justified.
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