Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Four studies are available in four different fish species. Of these, three were conducted for the required period of 96hrs and all gave very consistent answers. The study that showed the lowest value established the lower end of an LC50 range as 50mg/l.

Two studies have been carried out using Daphnia magna. These indicate that 2 -(2-butoxyethoxy)ethyl acetate is of low toxicity to invertebrates. D magna is the preferred species for this trophic level. One of the studies was not performed for the normally required 48hrs (only 24hr studies), however it showed a slightly lower EC50 value and is therefore selected as the key parameter. A correction for the shorter test duration is not required as a test for the requisite period gave a higher result.

There is no toxicity data for algae available for 2 -(2 -butoxyethoxy)ethyl acetate. However, there is data available for a read across substance 2 -butoxyethyl acetate whichi is sufficient to meet the requirements of the end point. A read across justification is attached as a separate document to chapter 13 of the IUCLID. This concludes that the read across is both justified and likely to be conservative and over-predict the toxicity of 2 -butoxyethyl acetate. Two experimentally derived results for the latter are available, both showing relatively low toxicity to the species. The study used as the key study shows the lower of the two results and is to a modern protocol. It is deemed reliable, although the available publication is not particularly detailed. The data is sufficient to judge with confidence that the substance is of low toxicity to algae. The data is also sufficient to provide evidence that this trophic level does not provide the critical NOEC for use in deriving the PNEC for the aquatic compartment so the absence of accurate data for the target substance itself is of low concern.

In a reliable micro-organism inhibition test using activated industrial sludge, 2 -2(butoxyethoxy)ethyl acetate caused no inhibition of the sludge respiration up to the maximum tested concentration of 1575mg/l.

There is no chronic toxicity data available for fish. For invertebrates, a semi-static study carried out to an AFNOR protocol (similar to an OECD guideline study but shorter duration), Ceriodaphnia Dubai were exposed to 2 -(2 -butoxyethoxy)ethyl acetate for 7 days. An EC10 for reproduction of 10.84mg/l was established.

Testing for toxicity to sedment and soil dwelling organisms is not deemed scientifically justified.