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EC number: 225-805-6
CAS number: 5089-70-3
There are no in vivo data on the
toxicokinetics of (3-chloropropyl)triethoxysilane. The following summary
has therefore been prepared based on validated predictions of the
physicochemical properties of the substance itself and its hydrolysis
products. (3-chloropropyl)triethoxysilane is a moisture-sensitive,
volatile liquid that hydrolyses slowly in contact with water (half-life
35 hours at pH 7), generating ethanol and 3-chloropropylsilanetriol.
Human exposure can occur via the inhalation or dermal routes. Relevant
inhalation and dermal exposure would be predominantly to the parent
substance. The toxicokinetics of ethanol is discussed elsewhere and is
not included in this summary.
oral exposure is not expected for this substance.
exposure would be to the parent substance. The molecular weight of 3-chloropropyltriethoxysilane
is not ideal for dermal absorption, but it
would not preclude it. The predicted water solubility (33 mg/l) and
predicted log Kow (3.4) of 3-chloropropyltriethoxysilane
suggest that this parent substance has the
potential to be absorbed quite effectively through the skin. There are
no reliable repeated dose toxicity studies to check for signs of
systemic availability. There were no signs of systemic toxicity in
several skin irritation studies.
water solubility and log Kow of 3-chloropropyltriethoxysilane
suggest that it will be absorbed directly
across the respiratory tract lining. There are no inhalation toxicity
studies on 3-chloropropyltriethoxysilane to check for signs of
The absorbed material is likely to be in the
form of the parent substance. The log Kow of the parent
substance means that it is likely to distribute into cells and the
intracellular concentration might be higher than the extracellular
concentration particularly in fatty tissues. The hydrolysis product is
likely to be widely distributed in the blood, but with a log Kow of
-1.1, uptake into organs and tissues will be limited by its diffusion
across membranes. Reliable toxicity studies do not provide evidence for
distribution to any particular organ or tissue.
There are no data on the metabolism of 3-chloropropyltriethoxysilane.
However, it will hydrolyse gradually to form ethanol and
3-chloropropylsilanetriol once absorbed into the body. Genetic toxicity
tests in vitro showed no observable differences in effects with
and without metabolic activation.
The water solubility and molecular weights of
the parent and hydrolysis products (predicted water solubility of 1.0E+6
mg/l) mean that, once absorbed, they are likely to be excreted by the
kidneys into urine.
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