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EC number: 225-805-6 | CAS number: 5089-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 68 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 6
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 9.7 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 6
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
(3-Chloropropyl)triethoxysilaneis a volatile liquid whichhydrolyses slowly(half-life 35 hours at pH 7)in contact with water, to formethanol and (3-chloropropyl)silanetriol. No reliable long-term mammalian toxicity data are available for (3-chloropropyl)triethoxysilane, therefore key data have been read-across from the related substance (3-chloropropyl)trimethoxysilane, which shares a common hydrolysis product. Further information on the use of read-across is given in Section 5.6.
There are two reliability score 1 studies for repeated inhalation of (3-chloropropyl)trimethoxysilane. The 90-day study was selected as the key study as it tested over the longest duration.
In the key 90-day inhalation study, microscopic examinations did not reveal any adverse findings in females exposed to 0.5 or 5 ppm. Eight of 10 male animals in the 0.5 ppm exposure group were reported as normal. The two remaining male animals exhibited minimal chronic cystitis of the urinary bladder. Nine of 10 male animals were reported as normal in the 5.0 ppm exposure group. The remaining male animals exhibited minimal chronic cystitis of the urinary bladder. Treatment-related histopathologic effects were observed in the 100 ppm group animals. Increased incidence of hyperplasia of the urinary bladder epithelium was noted in both sexes of this group.
It is not known whether the urinary bladder was inflated by a fixative before microscopic examination. Without inflation of the urinary bladder the relevance of the hyperplasia is questionable. Based onthe fact that the hyperplasia of the bladder was mild /minimal and in some cases associated with a minimal inflammation (cystitis) it can presumed that if the stimulus for the hyperplastic changes is removed the hyperplasia will resolve within a matter of weeks and the urinary bladder will return to a normal histologic appearance.A minimal/mild change of the urinary bladder not associated with any clinical symptoms or changes in urine parameters does not reflect a marked organ dysfunction. Therefore, the mild/minimal hyperplastic effects are not considered as adverse and the NOAEC is 100 ppm(813 mg/m3).
There are no repeat dose data for the oral and dermal routes. There is an OECD 414 developmental toxicity study conducted by the oral route (BSL, 2014).
(3-Chloropropyl)trimethoxysilanewas tested in an inhalation OECD 422 study (RCC, 2005), whole-body in rats, up to and including the highest concentration of 100 ppm. In this study there were no signs of adverse effects on reproduction or development parameters. The upper dose level was selected on the basis of the adverse findings at higher exposure concentrations in the 90-day study summarised above. Therefore based on these results the NOAEC was established to be at least 100 ppm (813 mg/m3) for these endpoints. Test animals were exposed for 6 hours per day, 5 days per week.
As discussed in Section 5.9 3-Chloropropyl)triethoxysilane was tested in an oral OECD 414 study (BSL, 2014) in which adverse maternal and foetal effects were noted at the highest dose tested, 1000 mg/kg bw/day. Therefore the maternal and foetal NOAEL was 300 mg/kg bw/day.
As discussed in Sections 5.6 and 5.9, the methanol hydrolysis product of the read-across substance, (3-chloropropyl)trimethoxysilane, and the ethanol hydrolysis product of the registered substance, (3-chloropropyl)triethoxysilanes, do not contribute to repeated-dose, reproductive or developmental toxicity in rats at the dose levels tested in these studies.
No significant effects were observed up to the maximum dose tested in an OECD 422 reproductive and developmental toxicity screening test in rats. It is therefore not possible to quantify DNELs for reproductive or developmental endpoints.
No quantitative DN(M)ELs could be derived for:
Acute toxicity – local effects (no effects)
Long-term toxicity – local effects (no effects)
Reproductive/developmental toxicity – no effects
Mutagenicity (not mutagenic)
Carcinogenicity (no data)
In the absence of any significant findings relating to reproductive or developmental endpoints in appropriate screening tests, the critical health effect is considered to be repeated-dose toxicity. (3-Chloropropyl)triethoxysilane is not classified as irritant, mutagenic, carcinogenic or sensitising.
The DNELs used for risk characterisation (workers) are therefore:
DNEL (long-term, inhalation): 68 mg/m3
DNEL (long-term, dermal): 9.7 mg/kg/dayGeneral Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 4.2 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 10
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
No exposure of consumers will occur during normal handling and use therefore DNELs via the dermal and inhalation routes are not calculated for consumers. An oral DNEL for the general population is needed for risk characterisation for indirect exposure via the environment. The DNEL used for risk characterisation (consumers) is:DNEL (long-term, oral): 4.2 mg/kg/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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