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EC number: 225-805-6 | CAS number: 5089-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 2 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 2 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.2 mg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 200 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 92 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.92 mg/kg sediment dw
- Assessment factor:
- 10
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 17.5 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Additional information
Short-term ecotoxicity data for three trophic levels are available for(3-chloropropyl)triethoxysilane. The relevant values are:
Fish:LC50 (96 h): 80 mg/l; NOEC: 58 mg/l
Daphnia: EC50 (48 h): 21.2 mg/l; NOEC: 2.15 mg/l (Mitterer, K.-E. 2002)
Daphnia: EC50 (48 h): 140 mg/l; NOEC: 100 mg/l (Hüls 1993)
Algae: EC50 (72 h): >819 mg/l; NOEC 237 mg/l
In addition, a 21-day NOEC value of ≥100 mg/L has been determined for the effects of(3-chloropropyl)triethoxysilaneon mortality and reproduction of Daphnia magna when expressed in terms of nominal concentrations. The result has been reinterpreted by the reviewer in terms of the mean measured concentration of the test substance to give a NOEC of ≥66 mg/L.
The PNEC is based on taking the NOECs derived in the algal test and long-term test with invertebrates into account and applying an assessment factor of 50. It is noted that the NOEC derived in the long-term invertebrate test is higher than the EC50 values derived in the short-term invertebrate and fish tests. The long-term invertebrate result has however been used as the basis for setting the PNEC for the following reasons:
· Both invertebrate tests are assigned reliability 1 but the test design used in the long-term test is more robust in terms of the numbers organisms that are exposed in each treatment.
· The apparent discrepancy in the relationship between the two results can be explained to a large degree by the shallow nature of the dose-response relationships in both tests which means that there is scope for overlap of the EC50 and NOEC values when other sources of variability in the test results are taken into account.
· There is no significant difference in the susceptibility of fish and invertebrates indicated in the short-term tests; therefore, there is no reason to expect that a long-term fish test would give a lower NOEC than the long-term invertebrate study.
Therefore, PNECaquatic is≥100/50 =≥2 mg/l.
Conclusion on classification
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