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Fish


PR022


In a reliable 96-hours acute toxicity study on Oryzias latipes performed according to OECD 203 and compliant to GLP (reliability category 1), the test item caused neither lethality nor abnormal behaviour or mobility at the applied limit concentration of nominal 100 mg/L (geometric mean measured concentration: 100 mg/L). Also no lethality nor abnormal behaviour or mobility was observed in the control and the solvent control (containing the amount of HCO-40 used in the treatment group). The following (no)effect concentrations were determined (geometric mean measured concentrations): LC50 (96 h): > 100 mg/L; LC0 (96 h): 100 mg/L; EC0 (96 h, behaviour & mobility): 100 mg/L.


Aquatic Invertebrates


PR002


In an acute immobilisation test to Daphnia magna according to OECD 202 no effects on daphnids were observed at the nominal limit concentration of 100 mg/L. Due to the very poor water solubility of the submission substance, a filtrated saturated solution prepared at 100 mg/L was used.
EC50 (48h) > 100 mg/L nominal concentration; NOEC (48h) = 100 mg/L nominal concentration


PR022 


In a daphnia magna reproduction test performed according to OECD 211 and compliant to GLP (reliability category 1) with semistatic test design (test medium renewal every 48 hours) no statistically significant effects were observed at the limit test item concentration of 30 mg/L (time weighted mean measured concentration). The following (no)effect concentrations (21 days) were determined:
LC50 (adult mortality) > 30 mg/L (TWA)
LOEC (reproduction, adult mortality, macroscopic effects) > 30 mg/L (TWA)
NOEC (reproduction, adult mortality, macroscopic effects) = 30 mg/L (TWA)
The validity criteria of the guideline were met.


PR112 


The test substance was tested in a daphnia magna reproduction test performed according to OECD 211 and compliant to GLP (reliability category 1). At the saturated solution of the test item with a nominal loading of 1.00 mg/L no biologically or statistically significant effects were determined. The No Observed Effect Loading (NOEL) and the Lowest Observed Effect Loading (LOEL) were assessed at:
NOEL: Saturated Solution (with the nominal loading of 1.00 mg/L)
LOEL: > Saturated Solution (with the nominal loading of 1.00 mg/L)
All effect values given are based on the saturated solution of the test item with the nominal loading of 1.00 mg/L.


Algae


PR002


In the algal study (OECD 201) no inhibition of growth of the freshwater green alga Desmodesmus subspicatus was found after 72 hours exposure to the test item. The NOEC for inhibition of specific growth rate and yield after 72 hours was 1.00 mg/L.
The test item caused a slight stimulation of the algae growth. All effect levels are based on the nominal concentration of the test item.


Microorganisms


PR002


A Respiration Inhibition Test with activated sludge according to OECD Guideline No. 209 was performed compliant to GLP with the submission substance (reliability category 1). TThe test was performed under static conditions with the nominal limit concentration of 1000 mg/L. The respiration rates of control, reference and test item concentrations were measured after a contact time of three hours, and the inhibitory effects of the test and reference concentrations were determined in comparison to the control respiration rates. No inhibition was observed at the tested limit concentration.


Validity criteria of the test guideline were fulfilled.


The test item is not toxic at concentrations >= 1000 mg/L to activated sludge of a municipal sewage treatment plant.

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