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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: according to information in OECD SIDS (2002)

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-hydroxyethyl)-1,3,5-triazinetrione
EC Number:
212-660-9
EC Name:
Tris(2-hydroxyethyl)-1,3,5-triazinetrione
Cas Number:
839-90-7
Molecular formula:
C9H15N3O6
IUPAC Name:
tris(2-hydroxyethyl)-1,3,5-triazinane-2,4,6-trione
Details on test material:
- Identity: Tris(2-hydroxyethyl) isocyanurate (CAS: 839-90-7)
- Source: Nissan Chemical Industries Ltd.; Lot No. 00915-1
- Purity: 99.0 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
- Age of the animals at study initiation: 5 weeks old

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Remarks:
for injection
Doses:
0, 500, 1,000, 2,000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
yes
Details on study design:
Control animals comprised a concurrent vehicle control group
Statistics:
Not applicable, because of no fatality. 

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
None
Clinical signs:
other: No treatment related clinical sign observed.
Gross pathology:
No treatment-related abnormalities.
Other findings:
There was no treatment-related adverse effect.

Applicant's summary and conclusion

Interpretation of results:
other: LD50 > 2000 mg/kg body weight
Conclusions:
There were no treatment related abnormalities. LD50 is greater than 2,000 mg/kg for both sexes.