Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 212-660-9 | CAS number: 839-90-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
THEIC is considered to behave quasi-inert in live organisms. This is consistent with the absence of any relevant adverse effects in all in vitro and in vivo toxicity studies and ecotoxicology tests performed with THEIC,and with its hydrolytic stability. However, THEIC has no bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
After oral uptake, THEIC is expected to be readily absorbed in the gastro-intestinal tract and to become systemically available, because of its high water solubility, moderately low molecular weight and hydrolytic stability.
After inhalation exposure, absorption and systemic availability of the rather small inhalable fraction of THEIC is expected to be 100%, because of its high water solubility.
Dermal absorption of THEIC is considered to be low. In view of its high water solubility and low n-octanol/water partition coefficient, THEIC is considered to be too hydrophilic to cross the lipid rich environment of the stratum corneum.
THEIC is considered to behave quasi-inert in live organisms. This is consistent with the absence of any adverse effects in all in vitro and in vivo toxicity studies and ecotoxicology tests performed with THEIC, and with its hydrolytic stability. However, THEIC does not have a bioaccumulation potential. Quasi-inert behaviour of another structurally similar substance is reported for cyanuric acid or 1,3,5-triazinetrione (EC No. 203-618-0, CAS No. 108-80-5). Based on the similarities of these two substances read-across of toxicological data is proposed. The results of toxicokinetic studies performed with 14C labelled cyanuric acid in rats, dogs and human volunteers demonstrating rapid excretion of un -metabolised cyanuric acid via urine and/or faeces can be considered as supporting evidence for the quasi -inert behaviour of THEIC.
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