Tris(2-hydroxyethyl)-1,3,5-triazinetrione

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study under GLP

Remarks:

(as given in OECD SIDS)

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes

Analytical monitoring:

yes

Test organisms (species):

Oryzias latipes

Test type:

semi-static

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Duration:

96 h

Dose descriptor:

LC10

Effect conc.:

100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Sublethal observations / clinical signs:

- Measured concentrations (as mg/L): <0.9 for control, 91.9 for the test solution at the beginning of the test; <0.9 for control, 92.0 for the test solution after 24 h
- Abnormal response: No abnormal responses in the test solution and control during exposure
- Reference substance result: LC50 of copper sulfate pentahydrate at 96 h; 1.5 mg/L.

Nominal concentrations (as mg/L): 0 and 100  
Measured concentrations (as mg/L): 91.9(Day 0)-92.0(Day 1)
Unit [results expressed in what unit]: % survival after 24, 48, 72, 96 h
Element value: 96h-LC50 is above 100 mg/L based on nominal concentration
Statistical results: binomial

- Biological observations: No abnormal response at the test 
concentration and control during the exposure.

- Table showing cumulative mortality 
_____________________________________________________
 Nominal        Measured      Cumulative mortality 
Concentration Concentration            (%) 
 (mg/L)          (mg/L)      24h    48h    72h    96h
Control           <0.9        0      0      0      0
  100           91.9-92.0     0      0     10     10

Conclusions:

96h-LC50 of tris(2-hydroxyethyl) isocyanurate was greater than 100 mg/L and 96h-LC10 of that was 100 mg/L.

Description of key information

LC50 (96h) >100 mg/L for Oryzias latipes (OECD TG 203)

Additional information

Value used for CSA:LC50 for freshwater fish: > 100 mg/L