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EC number: 202-908-4 | CAS number: 101-02-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Details on test material:
- Lot # TPPX-Z18-04080A (Borg-Warner)
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: 10% w/v in Mineral Spirits
- Controls:
- no
- Amount / concentration applied:
- The test substance was in a suspension (10 % w/v) in Mineral Spirits.
- Duration of treatment / exposure:
- 24 hr application to skin, followed by 24 hr rest. Repeated for 10 applications.
- Observation period:
- 24 and 48 hrs after challenge, which followed 2 week rest period after cycle of 10 applications (20 days)
- Number of animals:
- 10 male
- Details on study design:
- Exposure to skin for 24 hrs, followed by 24 hr rest period, repeated for 10 applications. A two-week rest period followed the tenth skin application after which the skin was challenged and observed for 24 and 48 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.4
- Max. score:
- 1
- Reversibility:
- other: erthyma disappeared in more than half of the animals within 24 hrs, no information about longer follow-up period
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No signs of edema in any of the animals.
- Irritant / corrosive response data:
- Full individual animal data are provided in the attached table.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- The results of this study show only slight irritation (mean PDII of 1 at 24 hrs and a mean PDII of 0.4 at 48 hrs) after 10 repeated 24 hr applications to the skin and a subsequent challenge after a 2 week rest period.
- Executive summary:
The results indicate that TPP is slightly irritating to the skin and not a skin sensitizer.
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