Registration Dossier
Registration Dossier
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EC number: 205-250-6 | CAS number: 136-52-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jusqu'à 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Patty's Toxicology Volumes 1-9 5th ed
- Author:
- Bingham E, Cohrssen B, Powell CH
- Year:
- 2 001
- Bibliographic source:
- John Wiley & Sons. New York, NY, USA, p. 5:728
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexanoic acid
- EC Number:
- 205-743-6
- EC Name:
- 2-ethylhexanoic acid
- Cas Number:
- 149-57-5
- Molecular formula:
- C8H16O2
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Non disponible
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Non disponible
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Non disponible
- Duration of exposure:
- Non disponible
- Doses:
- Non disponible
- No. of animals per sex per dose:
- Non disponible
- Control animals:
- not specified
- Details on study design:
- Non disponible
- Statistics:
- Non disponible
Results and discussion
- Preliminary study:
- Pas applicable
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 690 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Non disponible
- Clinical signs:
- other: Non disponible
- Gross pathology:
- Non disponible
- Other findings:
- Non disponible
Applicant's summary and conclusion
- Interpretation of results:
- other: Pas de classification
- Conclusions:
- La partie organique de la substance à enregistrer (acide ethylhexanoique) n'apparait pas comme nocive (DL50 par voie cutanée supérieure à 2000 mg/kg de poids corporel) pour les cochons d'Inde les conditions de test utilisées.
- Executive summary:
De l'acide ethylhexanoique a été administrée à des groupes de cochon d'Inde par voie cutanée. Une DL50 de 5690 mg/kg de poids corporel a été établie pour l'acide ethylhexanoique.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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