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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Jusqu'à 2001
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Patty's Toxicology Volumes 1-9 5th ed
Author:
Bingham E, Cohrssen B, Powell CH
Year:
2001
Bibliographic source:
John Wiley & Sons. New York, NY, USA, p. 5:728

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
2-ethylhexanoic acid
EC Number:
205-743-6
EC Name:
2-ethylhexanoic acid
Cas Number:
149-57-5
Molecular formula:
C8H16O2
Test material form:
liquid
Specific details on test material used for the study:
Non disponible

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
Non disponible

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Non disponible
Duration of exposure:
Non disponible
Doses:
Non disponible
No. of animals per sex per dose:
Non disponible
Control animals:
not specified
Details on study design:
Non disponible
Statistics:
Non disponible

Results and discussion

Preliminary study:
Pas applicable
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 690 mg/kg bw
Based on:
test mat.
Mortality:
Non disponible
Clinical signs:
other: Non disponible
Gross pathology:
Non disponible
Other findings:
Non disponible

Applicant's summary and conclusion

Interpretation of results:
other: Pas de classification
Conclusions:
La partie organique de la substance à enregistrer (acide ethylhexanoique) n'apparait pas comme nocive (DL50 par voie cutanée supérieure à 2000 mg/kg de poids corporel) pour les cochons d'Inde les conditions de test utilisées.
Executive summary:

De l'acide ethylhexanoique a été administrée à des groupes de cochon d'Inde par voie cutanée. Une DL50 de 5690 mg/kg de poids corporel a été établie pour l'acide ethylhexanoique.