Registration Dossier
Registration Dossier
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EC number: 203-561-1 | CAS number: 108-21-4
Endpoint summary
Administrative data
Description of key information
Adequate studies of the dermal sensitization potential of isopropyl acetate were not found. Other analogue alcohol esters of acetic acid, for example ethyl acetate and butyl acetates, have been studied and are not dermal sensitisers.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Guseinov et al (1986) reported that cutaneous application of a 1:2 dilution of isopropyl acetate did not induced cutaneous reaction. This study was not reported in sufficient detail to judge its reliability
In guideline (OECD 406) studies using ethyl acetate and isobutyl acetate, neither close structural analog was sensitizing in the guinea pig maximization test. In a mouse ear swelling test, n-butyl acetate was not sensitising. The evidence available suggests that isopropyl acetate is not likely to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Migrated from Short description of key information:
No studies of the respiratory sensitization potential of isopropyl acetate were found.
Justification for classification or non-classification
Based on limited data available for isopropyl acetate, and reliable dermal sensitization results available for the structural analog ethyl acetate, no classification is recommended.
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