Registration Dossier

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A GLP-study in Pimephales promelas and a non-GLP study in Oncorhynchus mykiss, both studies according or equivalent to OECD guideline 203 are available as key studies for propylene glycol methyl ether acetate. These studies are supported by a GLP-study in Oryzias latipes and a non-GLP study in Oncorhynchus mykiss.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
130 mg/L

Additional information

In an acute toxicity study with Oncorhynchus mykiss, based on the nominal concentrations of propylene glycol methyl ether acetate ranging from 100 to 1,000 mg/l, the 96 h-LC0 was determined to be 100 mg/l. The 96-hour LC100 was determined to be 180 mg/l. An approximation of the 96-hour LC50 can be made by calculating the geometric mean between 96-hour LC0 and 96-hour LC100. Using this approach an LC50 value of 134 mg/l was calculated. The no observed effect concentration (NOEC) was determined to be greater than 100 mg/l. A 96-hour LC50 of 161 mg/l was established in an acute toxicity study with Pimephales promelas, based on nominal concentrations. Another acute toxicity study with Oncorhynchus mykiss using exposure concentrations from 100 to 1,000 mg/l the 96-hour LC50 was determined to be 130 mg/l, based on nominal concentrations. The Environment Agency of Japan studied the acute toxicity of propylene glycol methyl ether acetate to Oryzias latipes under semi-static conditions during 96 hours. The maximum exposure concentration was 100 mg/l. Based on the nominal concentrations, the 96-hour LC50 was determined to be superior to 100 mg/l. The test report from the Environment Agency of Japan is not available.