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EC number: 270-608-0 | CAS number: 68457-79-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979/11/21-1979/12/05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This non-GLP study is similar to current guidelines with deviations that warrant restriction.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: 16CFR1500.3
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 2 rather than 5 animals/sex were evaluated for toxicity and the skin of one animal/sex was abraded. Gross necropsy was not performed and minimal detail is provided in the report.
- Principles of method if other than guideline:
- Four rabbits were dosed at 20 g/kg and exposed dermally for 24 h under gauze dressing as described. If deaths occurred at the initial level, 3 additional groups of 4 rabbits are dosed at log intervals in an attempt to determine the LD 50.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts
- EC Number:
- 270-608-0
- EC Name:
- Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts
- Cas Number:
- 68457-79-4
- Molecular formula:
- {[(iso-C4H9O)0.64(C5H11O)0.36]PS2}2Zn - neutral, {[(iso-C4H9O)0.64(C5H11O)0.36]PS2}6Zn4O - basic
- IUPAC Name:
- Phosphorodithioic acid, mixed O,O-bis(iso-Bu and pentyl) esters, zinc salts
- Details on test material:
- Test material is described as amber liquid with specific gravity of 1.14
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals supplied by Nicholas Helf were approximately 8 weeks old and weighed between 2.2-2.6 kg when received. The animals were equilibrated to the laboratory for 1 week. Apparently healthy rabbits were selected for the test and identified by cage tags and indelible ear marks. Animals were housed 2/cage in suspended wire mesh cages. Fresh Purina rabbit chow and water were freely available. The animal room was maintained at 20-21°C and kept clean in accordance with AAALAC standards.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Immediately prior to dosing, the fur was clipped from the abdomen of the animals. The clipped area was 200 square cm. Abrasions were made in one half of the rabbits and extended the length of the exposure site. The abrasions scratched the stratum corneum but did not reach the derma or produce bleeding. Test material was applied once dermally under gauze patches, secured with adhesive tape, and wrapped around the trunks with an impervious material.
- Duration of exposure:
- Test material was held in contact with the skin for 24 h, at which time the wrappings were removed. The exposure site was wiped, but not washed, to remove any excess material.
- Doses:
- 20 g/kg
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- Dermal reactions were scored at 24 h by the Draize scoring system. The rabbits were observed daily for 14 days for signs of toxicity, pharmacological effects and mortality. Body weights were recorded pretest and in the survivors at 14 days.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 20 000 mL/kg bw
- Mortality:
- All animals survived the test.
- Clinical signs:
- other: Lethargy, diarrhea, ataxia, ptosis, alopecia, emaciation, yellow nasal discharge and sensitivity to touch were noted during the second week of observation. Well defined erythema and slight edema were noted at 24 h.
- Gross pathology:
- No data.
- Other findings:
- No data.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The test article, when administered dermally as received to 2 male and 2 female New Zealand white rabbits had an acute dermal LD50 of greater than 20.0 g/kg
- Executive summary:
In an acute dermal toxicity study, New Zealand White rabbits were exposed to 20 g/kg of the test substance. The LD50 on Day 14 post-exposure was greater than 20 g/kg. Toxic signs observed included lethargy, diarrhea, ataxia, ptosis, alopecia, emaciation, and yellow nasal discharge. Based on the results of this study, the test substance would not be classified in accordance with the classification system of GHS. This toxicity study is classified as acceptable and satisfies the guideline requirement for acute dermal toxicity in rabbits.
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