(2-methoxymethylethoxy)propanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented study report which meets basic scientific principles

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

PROCEDURE
This test (also called inhalation risk test) was performed in principle as described in OECD Guideline 403.
It demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation (usually 20 °C).

Young adult laboratory rats were purchased from a breeder. In general, the source and strain of the animals were not documented.
Several groups of usually 3 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods (e.g. 3 min, 10 min, 1, 3 or 7 or 8 hours). The exposure time not causing lethality was usually tested twice.

No analytical determination of the atmosphere concentrations was performed. The nominal concentration usually can be calculated as quotient of the amount of test substance weight loss during the exposure, which is given in the raw data, and the amount of air used during the exposure.

Group-wise documentation of clinical signs was performed over the 7- to 14-day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in the surviving animals.
The clinical signs and findings were reported in summarized form.

The study allows for an estimate of the length of time required to cause severe toxic effects resulting from exposure to an atmosphere saturated with vapours of the test substance. The exposure time causing 50 % lethality (LT50) can be estimated from such a study as described for the LD50. Furthermore, using the nominal concentration, vapour pressure and LT50, in many cases a 4-hour LC50 can be estimated using Haber's law.

(Inhalation Risk Test (IRT) in the rat: method according to Smyth et al., Am.Ind.Hyg. Ass.J. 23, 1962)

GLP compliance:

no

Test type:

other: Inhalation Risk Test (IRT)

Test material

Test material information

Constituent 1

Reference substance name:

(2-methoxymethylethoxy)propanol

EC Number:

252-104-2

EC Name:

(2-methoxymethylethoxy)propanol

Cas Number:

34590-94-8

Molecular formula:

C7H16O3

IUPAC Name:

2-[(1-methoxypropan-2-yl)oxy]propan-1-ol

Details on test material:

- Name of test material (as cited in study report): Methoxypropoxypropanol
- Physical state: liquid
- Substance number: 78/187
- Vapour pressure (20°C): 0.4 Torr

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

TEST ATMOSPHERE
- mean concentration of TS: 1.66 mg/l (275 ppm)

Duration of exposure:

7 h

No. of animals per sex per dose:

12 animals were used

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Effect level:

> 275 ppm

Exp. duration:

7 h

Mortality:

0%
(no animal died after application of the TS and during the observation period)

Clinical signs:

other: irritation of the mucosa: wiping of the snout, watery nose secretion, dyspnea, scrubby fur

Gross pathology:

no findings

Any other information on results incl. tables

No mortalities (0/12) after 7-hour exposure to an atmosphere enriched with the test substance vapour at 20°C.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Dipropylene glycol methyl ether is not acutely toxic via the inhalation route. Based on the LC0 > 275 ppm (1667 mg/m3) no classification is required according to EU criteria.