Registration Dossier
Registration Dossier
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EC number: 405-740-1 | CAS number: 47073-92-7 AROCY L-10
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- August-December 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study; not GLP-compliant
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- four animals used
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- other: amber liquid
- Details on test material:
- - Test Material: C-1054
- Description: Amber liquid
- Date Received: August 7, 19B6
- Storage: Temperature - monitored room (60-85°F)
- Density: 1.2208 g/ml
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- no data
- Duration of exposure:
- 24 hours
- Doses:
- Dose level: 5000 mg/kg
Dose volume: 4.1 ml/kg - No. of animals per sex per dose:
- 4 animals
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: No clinical signs noted
- Gross pathology:
- No pathological findings noted
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 on rabbits was found to be > 5000 mg/kg.
- Executive summary:
The LD50 was performed similar or equal to OECD 402 using rabbits; one dose level was tested and four animals used. The acute dermal LD50 was found to be > 5000 mg/kg.
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