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EC number: 202-859-9 | CAS number: 100-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Reliability score 2 on the basis of the weight of evidence found during review of public documents existing relating to toxicological data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Benzyl Alcohol
- Author:
- NPIRI (National Assoc. of Printing Ink Research Institute)
- Year:
- 1 974
- Bibliographic source:
- Raw Material Data Handbook, Vol.1:( Organic Solvents), 6,1974.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.1100 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days. - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzyl alcohol
- EC Number:
- 202-859-9
- EC Name:
- Benzyl alcohol
- Cas Number:
- 100-51-6
- Molecular formula:
- C7H8O
- IUPAC Name:
- phenylmethanol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 4 male/female rabbits
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 4 male/female rabbits
- Control animals:
- yes
- Details on study design:
- The test compound, dose of 2000 mg/kg bw was applied to the intact and abraded skin of rabbits for 24 hours under occlusive conditions.
The skin of rabbits was abraded with a scalpel blade prior to test application.
The area was wrapped with a gauze bandage and occluded with plastic wrap.
The bandages were removed and the backs washed 24 hours after application.
The rabbits were observed for a period of 14 days.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no signs of systemic or organ toxicity were noted.
- Clinical signs:
- other: no signs of systemic or organ toxicity were noted.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The compound exhibit low acute toxicity for the dermal route the LD50 values are > 2000mg/kg bw. Data published in the NPIRI: Raw Mater. Data Handb. Vol. 1, 6 (1974) report show that after acute dermal application is > 2000 mg/kg bw to the intact and abraded skin of rabbits for 24 hours under occlusive conditions, no signs of systemic or organ toxicity were noted. On this basis dermal classification of benzyl alcohol deemed to be non-toxic.
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