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EC number: 202-859-9 | CAS number: 100-51-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficiently documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- 10 male rats received a single oral application per gavage of 1.0, 1.2, 1.4, 1.5, 2.0 and 2.1 ml/kg bw (= ca. 1045, 1254, 1463, 1467, 2090 and 2195 mg/kg bw) of the test substance. Post-exposure period was 14 days.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Benzyl alcohol
- EC Number:
- 202-859-9
- EC Name:
- Benzyl alcohol
- Cas Number:
- 100-51-6
- Molecular formula:
- C7H8O
- IUPAC Name:
- phenylmethanol
- Details on test material:
- - Name of test material (as cited in study report): Benzylalkohol
no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- male Wistar rats, SPF, weight 160 - 180 g; husbandry: 5 animals per cage; breeder: Winkelmann
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- single oral application per gavage (no further data)
- Doses:
- 1.0, 1.2, 1.4, 1.5, 2.0 and 2.1 ml/kg bw (= ca. 1045, 1254, 1463, 1467, 2090 and 2195 mg/kg bw)
- No. of animals per sex per dose:
- 10 male rats per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily
- Frequency of weighing: start and end of study
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight - Statistics:
- LD50 according Fink and Hund, Arzneimittelforschung (1965), 15, 624
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.55 mL/kg bw
- 95% CL:
- 1.42 - 1.7
- Remarks on result:
- other: corresponding to 1620 mg/kg bw (density: 1.045 g/mL)
- Sex:
- male
- Dose descriptor:
- other: NOAEL
- Effect level:
- 1 mL/kg bw
- Remarks on result:
- other: corresponding to 1045 mg/kg bw
- Mortality:
- dose 1.0 ml/kg bw, mortality 0/10; dose 1.2 ml/kg bw, mortality 1/10; dose 1.4 ml/kg bw, mortality 2/10; dose 1.5 ml/kg bw, mortality 6/10; dose 2.0 ml/kg bw, mortality 8/10; dose 2.1 ml/kg bw, mortality 10/10;
- Clinical signs:
- other: 1.0 ml/kg bw: no clinical findings from 1.2 ml/kg bw onwards: sedation, side and prone-position, bloody eyes and reduction of general condition
- Gross pathology:
- no data
- Other findings:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Executive summary:
10 male rats received a single oral application per gavage of 1.0, 1.2, 1.4, 1.5, 2.0 and 2.1 ml benzyl alcohol/kg bw (= 1045, 1254, 1463, 1467, 2090 and 2195 mg/kg bw; density: 1.045 g/ml) and were observed for 14 days. Clinical signs were observed from 1.2 ml/kg bw onwards and included sedation, side and prone position, bloody eyes and reduction of general condition. The resulting LD50 was 1.55 ml/kg bw (= 1620 mg/kg bw) (Bayer AG 1978).
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