Registration Dossier
Registration Dossier
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EC number: 202-859-9 | CAS number: 100-51-6
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- publication
- Title:
- Ocular tolerance of preservatives on the murine cornea
- Author:
- Furrer P, Mayer JM, Plazonnet B, Gurny R
- Year:
- 1 999
- Bibliographic source:
- Europ J Pharmaceutics, Biopharmaceutics 47, 105-112
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- instilling testsubstance on the murine cornea (3 days) and determing the microlesions on the conrnea
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Benzyl alcohol
- EC Number:
- 202-859-9
- EC Name:
- Benzyl alcohol
- Cas Number:
- 100-51-6
- Molecular formula:
- C7H8O
- IUPAC Name:
- phenylmethanol
- Details on test material:
- analytical grade
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: dropps on the cornea
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- 4 times per day, 2.5 hours apart
- Post exposure period:
- no
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 %
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
- Details on results:
- 0.5 % benzyl alcohol dropped on the murine cornea 4 times a day, each 2.5 hours apart for 3 days
resulted in a 10 % damage of the corneal surface
Any other information on results incl. tables
0.5 % benzyl alcohol dropped on the murine cornea 4 times a day, each 2.5 hours apart for 3 days resulted in a 10 % damage of the corneal surface
Applicant's summary and conclusion
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