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EC number: 207-938-1 | CAS number: 502-44-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16th to 19th September 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Proprietary study conducted according to guidelines and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hexan-6-olide
- EC Number:
- 207-938-1
- EC Name:
- Hexan-6-olide
- Cas Number:
- 502-44-3
- Molecular formula:
- C6H10O2
- IUPAC Name:
- oxepan-2-one
- Reference substance name:
- e-caprolactone
- IUPAC Name:
- e-caprolactone
- Details on test material:
- e-Caprolactone, a liquid, was supplied by Solvay S.A. Brussels. Batch No: WA2809/0791. Purity: >99%. Prior to dosing, the substance was stored in a refrigerator.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Three SPF-derived male New Zealand White rabbits (2.5-3.0kg) were obtained from Harlan Olac and acclimatised for 11 days. The rabbits were individually housed in stainless steel wire cages; sawdust, woodchip, or any other extraneous material that may cause skin irritation were excluded. The rabbits received 80g standard laboratory diet per day, and they had free access to the food and water. The animal room was maintained at a temperature of 19-20oC, relative humditiy 55-72%, artificial light from 7am till 7pm, radio-sound from 7am till 7pm, and approximately 16 air changes per hour.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5g of test material 2x3cm area of skin.
- Duration of treatment / exposure:
- The patches were secured in place for 4 hours.
- Observation period:
- Observations were made at 30-60 minutes, and 24, 48 and 72 hours after substance removal.
- Number of animals:
- Three male rabbits.
- Details on study design:
- Areas on the backs of 3 rabbits were shaved (2x3cm). 0.5g e-Caprolactone was applied directly to the shaved skin, and held in place by occlusive Blenderm tape and standard adhesive tape. Elizabethan collars were fitted to the rabbits to prevent them disturbing the treatment area. The substance was left in place for 4 hours. Following this the collars and tape were removed, and the skin wiped to remove any remaining residue. Observations were made at 30 minutes, and 24, 48 and 72 hours after substance removal.
Treatment sites were scored based on erythema and eschar formation, and oedema formation (according to the scoring system in OECD 404).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: No effects noted
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: No effects noted
- Irritant / corrosive response data:
- No erythma or oedema was observed in the three rabbits after 4 hours skin exposure to e-Caprolactone.
- Other effects:
- No other effects reported.
Any other information on results incl. tables
No erythma or oedema was observed in the three rabbits after 4 hours skin exposure to e-Caprolactone, at any time point post-substance removal.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The application of e-Caprolactone caused no irritation to the shaven intact skin of 3 rabbits, therefore the substance was classified as non-irritant according to EEC labelling regulations.
- Executive summary:
The primary irritation of e-Caprolactone to rabbit skin was investigated. 0.5 g e-Caprolactone was applied directly to an area of shaved skin on the backs of the rabbits (2x3cm), and held in place for 4 hours using occlusive tape. After removal of the tape the skin was wiped to remove any remaining residue, and observations were made at 0.5, 24, 48 and 72 hours after removal. No erythema or oedema was observed in the rabbits at any time point. Classification as a skin irritant is not required on the basis of this study.
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