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EC number: 231-494-8 | CAS number: 7585-41-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see the category read-across justification in the category object.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across: supporting information
- Key result
- Conc. / dose:
- 0.03 mg/L
- Type:
- BCF
- Value:
- < 6.9 L/kg
- Time of plateau:
- 42 d
Reference
Description of key information
Accumulation in organisms is not to be expected.
Key value for chemical safety assessment
Additional information
Two studies, conducted with two analogues of the category (CAS 5281-04-9 and CAS 73612-29-0), were performed according to OECD 305. Fish (Cyprinus carpio) were exposed to CAS 5281-04-9 in concentrations of 0.3 mg/L and 0.03 mg/L, respectively. The test was terminated after 6 weeks of exposure. At a substance concentrations of 0.3 mg/L a BCF of 0.7 - 1.8 was determined. At a concentration of 0.03 mg test substance/L a BCF < 6.9 was detected (JETOC, 1992).
In a second study, fish (Cyprinus carpio) were exposed to CAS 73612-29-0 in concentrations of 0.1 mg/L and 0.01 mg/L, respectively (Dainippon Ink and Chemicals Inc. 2006). The test was terminated after 28 days of exposure. At a substance concentrations of 0.1 mg/L a BCF of <= 4.4 was determined. At a concentration of 0.01 mg test substance/L a BCF <= 0.44 was detected. Even though only limited information is available of this study, the result can be used to support the overall conclusion in a weight of evidence approach.
Furthermore, in a third study, Cyprinus carpio was exposed to CAS 15782 -05 -5 in concentrations of 0.1 and 0.01 mg/L, respectively (NITE 1996). After 6 weeks of exposure a BCF value af 0.4 - 1 L/kg was determined for the test concentration of 0.1 mg/L. For the second test concentration of 0.01 mg/L a BCF value of <= 0.4 L/kg was determined. Also for this study only limited information is available. Nevertheless, the results support the overall conclusion as well
Overall, the category is assessed to not significantly accumulate in organisms. Furthermore, no bioaccumulation is expected as each of the category members have log Kow values <3.
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