Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-951-9 | CAS number: 101-54-2
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited documentation
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Study type:
- other: biological monitoring
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- other: biological monitoring of 4-ADPA
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-(4-aminophenyl)aniline
- EC Number:
- 202-951-9
- EC Name:
- N-(4-aminophenyl)aniline
- Cas Number:
- 101-54-2
- Molecular formula:
- C12H12N2
- IUPAC Name:
- N1-phenylbenzene-1,4-diamine
- Details on test material:
- no data
Constituent 1
Method
- Subjects:
- - Number of subjects exposed: 669
- Route of exposure:
- other: occupational
- Reason of exposure:
- other: occupational
Results and discussion
- Clinical signs:
- Measurment: 4 -ADPA-adducts in blood (4 -ADPA-hemoglobin-adducts) (µg/l), free and total 4 -ADPA in urine (µg/l)
Any other information on results incl. tables
In the frame of the occupational surveillance program the levels of 4-ADPA-adducts in blood and of 4-ADPA in urine are measured at least once a year in each worker of a 4-ADPA manufacturing plants. In the previous years, e.g. 2202, the measured results were below the detection limits.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
