Registration Dossier
Registration Dossier
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EC number: 202-951-9 | CAS number: 101-54-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute toxicity of 4-ADPA to fish (Brachydanio rerio) was conducted in a static test according to draft guideline of the Federal Environmental Agency-Lethal effects towards zebrafish-Brachydanio rerio (UBA,May 1984). After 96 hours of exposure a LC50 of 1.9 mg/L (nominal) was obtained (Bayer, 2002). Considering the effect of degradation in nutrient medium, an effective concentration of 1.17 mg/l is calculated and reported here as a more realistic LC50.
Key value for chemical safety assessment
Additional information
The half-life time of 3.5 d (BIS, 2004) is used here in IUCLID 5 for the calculation of effective concentration as geometric mean instead of 2.5 d used in OECD SIDS. The value of 2.5 d was extrapolated from the half-life time at 50°C, but 3.5 d was real experimental result at 20°C (BIS, 2004).
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