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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: OSHA Toxicity Screening Test. Limited documentation of the study. No detailed description of the test substance available.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Guideline:
other: OSHA Toxicity Screening Test
GLP compliance:
no
Remarks:
pre-GLP
Test type:
other: single dose
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
other: albino rabbits
Sex:
male

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Remarks:
undiluted
Doses:
Dosage: 5000 mg/kg
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 0, 7 and 14 days
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
In the observation period of 14 days, 1 of 6 experimental animals died.
Clinical signs:
Dodecyl pentadecyl methacrylate was severely irritating to the skin of the albino rabbit. Skin changes at 24 hours were characterized by pale red to red, well-defined erythema, moderate edema and second degree burns. Escharosis, wrinkling and fissuring were observed at 7 and 14 days.
Body weight:
As signs of intoxiciation, an adverse effect on body weight was observed in most of the test animals.
Gross pathology:
Necropsy examination revealed hemorrhaged lungs in rabbit No. 2 and 3; and emaciation and depletion of body fat stores in rabbit No. 3, 4 and 6.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute dermal toxicity study with Dodecyl pentadecyl methacrylate with male albino rabbits, an LD50 > 5000 mg/kg was observed.
Executive summary:

In an acute dermal OSHA toxicity screening test with Dodecyl pentadecyl methacrylate (purity: unknown), the test substance was administered undiluted with a dosage of 5000 mg/kg. b.w.

The determined LD50 was > 5000 mg/kg in male albino rabbits.

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